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Listing targeted studies

598 articles and 795 studies.
ID Title Authors Year Organism Cell type Subcellular fraction Techniques Sites
632 A palmitoylation switch mechanism in the regulation of the visual cycle. Xue L et al. 2004 Spodoptera frugiperda Sf21 Total membrane Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
195 Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling. Rossin A et al. 2009 Homo sapiens HEK293 Total cell lysate Inhibition of palmitoylation with 13-oxypalmitate, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange), Point mutation of substrate, Labeling of substrate with [3H]palmitate O00220 [3] Show
196 Molecular recognition of the palmitoylation substrate Vac8 by its palmitoyltransferase Pfa3. Nadolski MJ et al. 2009 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yPH499 Total membrane Point mutation of substrate, Labeling of substrate with [3H]palmitoyl-CoA, Over-expression of palmitoyltransferase P39968 [3] Show
197 RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase. Fairbank M et al. 2012 Chlorocebus aethiops COS7 Total cell lysate ABE (Acyl-Biotin Exchange), Over-expression of palmitoyltransferase, Point mutation of substrate, Truncation of substrate Q9R049-2 [6] Show
198 Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters. DeSouza S et al. 2002 Chlorocebus aethiops COS7 Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Point mutation of substrate Q9WTW1-4 [1] Show
199 Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters. DeSouza S et al. 2002 Chlorocebus aethiops COS7 Total cell lysate Labeling of substrate with [3H]palmitate Show
200 Palmitoylation regulates the clustering and cell surface stability of GABAA receptors. Rathenberg J et al. 2004 Rattus norvegicus Hippocampal neuron Total cell lysate Labeling of substrate with [3H]palmitate Show
201 Palmitoylation regulates the clustering and cell surface stability of GABAA receptors. Rathenberg J et al. 2004 Chlorocebus aethiops COS7 Total cell lysate Cellular localization of substrate by immunofluorescence, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, Point mutation of substrate P22723 [5] Show
202 Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains. Heakal Y et al. 2011 Homo sapiens MDA-MB-231 Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
203 Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains. Heakal Y et al. 2011 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P30989 [2] Show
204 Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor. Crise B et al. 1992 Homo sapiens HeLa To be annotated Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
205 Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels. Jeffries O et al. 2010 To be annotated To be annotated To be annotated To be annotated Q08460-5 [3] Show
207 Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling. Osterhout JL et al. 2003 To be annotated To be annotated To be annotated To be annotated O15492 [1] Show
208 Isoform-specific palmitoylation of JNK regulates axonal development. Yang G et al. 2012 To be annotated To be annotated To be annotated To be annotated P53779 [2] Show
209 S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. Cheng H et al. 2009 To be annotated To be annotated To be annotated To be annotated Q92542 [1], Q96BI3 [2] Show
210 Identification of palmitoylation sites within the L-type calcium channel beta2a subunit and effects on channel function. Chien AJ et al. 1996 To be annotated To be annotated To be annotated To be annotated Q8VGC3-2 [2] Show
211 The 5-hydroxytryptamine(1A) receptor is stably palmitoylated, and acylation is critical for communication of receptor with Gi protein. Papoucheva E et al. 2004 To be annotated To be annotated To be annotated To be annotated Q64264 [2] Show
633 A palmitoylation switch mechanism in the regulation of the visual cycle. Xue L et al. 2004 Bos taurus retinae Total cell lysate Mass Spectrometry Q28175-1 [3] Show
214 Palmitoylation is a sorting determinant for transport to the myelin membrane. Schneider A et al. 2005 To be annotated To be annotated To be annotated To be annotated P60202 [3] Show
215 S-palmitoylation modulates human estrogen receptor-alpha functions. Acconcia F et al. 2004 To be annotated To be annotated To be annotated To be annotated P03372 [1] Show
216 S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment. McClure ML et al. 2014 To be annotated To be annotated To be annotated To be annotated Show
217 Palmitoylation of the Autographa californica multicapsid nucleopolyhedrovirus envelope glycoprotein GP64: mapping, functional studies, and lipid rafts. Zhang SX et al. 2003 To be annotated To be annotated To be annotated To be annotated P17501 [1] Show
218 The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ. Keller CA et al. 2004 To be annotated To be annotated To be annotated To be annotated Show
219 Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane. Wiedmer T et al. 2003 To be annotated To be annotated To be annotated To be annotated O15162 [5] Show
220 The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity. Zhou B et al. 2004 To be annotated To be annotated To be annotated To be annotated P27701-1 [5], P27701-2 [5] Show
221 Palmitoylation-dependent control of degradation, life span, and membrane expression of the CCR5 receptor. Percherancier Y et al. 2001 To be annotated To be annotated To be annotated To be annotated P51681 [3] Show
222 Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation. Morrow IC et al. 2002 To be annotated To be annotated To be annotated To be annotated O08917 [1] Show
223 The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity. Ponimaskin EG et al. 2002 To be annotated To be annotated To be annotated To be annotated P97288-2 [3] Show
224 Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. Takimoto K et al. 2002 To be annotated To be annotated To be annotated To be annotated Q9JM59 [2], Q9JM47 [2] Show
225 Palmitoylation of the V2 vasopressin receptor carboxyl tail enhances beta-arrestin recruitment leading to efficient receptor endocytosis and ERK1/2 activation. Charest PG et al. 2003 To be annotated To be annotated To be annotated To be annotated P30518 [2] Show
634 Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1). Segal-Salto M et al. 2016 Homo sapiens HEK293 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with 17-ODYA (17-octadecynoic acid), Over-expression of dominant-negative palmitoyltransferase, Over-expression of palmitoyltransferase, Point mutation of substrate P50897 [1] Show
227 Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling. Han JM et al. 2002 To be annotated To be annotated To be annotated To be annotated Q13393 [2] Show
228 Transmembrane TNF (pro-TNF) is palmitoylated. Utsumi T et al. 2001 To be annotated To be annotated To be annotated To be annotated P01375 [0] Show
62 Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum. Abrami L et al. 2008 Homo sapiens HeLa Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Point mutation of substrate, Truncation of substrate O75581 [2] Show
73 All ras proteins are polyisoprenylated but only some are palmitoylated. Hancock JF et al. 1989 To be annotated To be annotated To be annotated To be annotated P01111 [1], P01112 [2] Show
20 Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. Koegl M et al. 1994 Chlorocebus aethiops L Cells Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P39688 [2], P06240 [2] Show
229 Palmitoylation of the human bradykinin B2 receptor influences ligand efficacy. Pizard A et al. 2001 To be annotated To be annotated To be annotated To be annotated P30411-2 [2] Show
230 Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae. Koziak K et al. 2000 To be annotated To be annotated To be annotated To be annotated P49961 [1] Show
231 Palmitoylation of the Rous sarcoma virus transmembrane glycoprotein is required for protein stability and virus infectivity. Ochsenbauer-Jambor C et al. 2001 To be annotated To be annotated To be annotated To be annotated P03396 [2] Show
232 Single site alpha-tubulin mutation affects astral microtubules and nuclear positioning during anaphase in Saccharomyces cerevisiae: possible role for palmitoylation of alpha-tubulin. Caron JM et al. 2001 To be annotated To be annotated To be annotated To be annotated P09733 [1] Show
234 Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells. Gonelle-Gispert C et al. 2000 To be annotated To be annotated To be annotated To be annotated Show
235 Lack of palmitoylation redirects p59Hck from the plasma membrane to p61Hck-positive lysosomes. Carréno S et al. 2000 To be annotated To be annotated To be annotated To be annotated Show
237 Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles. Lutjens R et al. 2000 To be annotated To be annotated To be annotated To be annotated Show
239 Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis. Kumano-Kuramochi M et al. 2013 To be annotated To be annotated To be annotated To be annotated P78380 [2] Show
240 Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling. Poggi M et al. 2013 To be annotated To be annotated To be annotated To be annotated Show
241 The role of MPP1/p55 and its palmitoylation in resting state raft organization in HEL cells. Biernatowska A et al. 2013 To be annotated To be annotated To be annotated To be annotated Show
242 Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants. Chen L et al. 2013 To be annotated To be annotated To be annotated To be annotated Q86W47 [1] Show
243 Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43. Kong E et al. 2013 To be annotated To be annotated To be annotated To be annotated P97823 [1] Show
244 Membrane localization of a rice calcium-dependent protein kinase (CDPK) is mediated by myristoylation and palmitoylation. Martín ML et al. 2000 To be annotated To be annotated To be annotated To be annotated P53683 [2] Show
245 Dual lipidation of the brain-specific Cdc42 isoform regulates its functional properties. Wirth A et al. 2013 To be annotated To be annotated To be annotated To be annotated P60766-1 [2] Show
246 Palmitoylation of estrogen receptors is essential for neuronal membrane signaling. Meitzen J et al. 2013 To be annotated To be annotated To be annotated To be annotated Show
247 DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes. Kim KS et al. 2013 To be annotated To be annotated To be annotated To be annotated Q99497 [3] Show
248 Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants. Antinone SE et al. 2013 To be annotated To be annotated To be annotated To be annotated P00441 [1] Show
249 In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. Oku S et al. 2013 To be annotated To be annotated To be annotated To be annotated O35095 [2] Show
250 Palmitoylation on conserved and nonconserved cysteines of murine IFITM1 regulates its stability and anti-influenza A virus activity. Hach JC et al. 2013 To be annotated To be annotated To be annotated To be annotated Q9D103 [4] Show
251 Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2. Milde S et al. 2013 To be annotated To be annotated To be annotated To be annotated Q8BNJ3 [2] Show
252 Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2. Wei X et al. 2012 To be annotated To be annotated To be annotated To be annotated Q80Z19 [3] Show
254 Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications. McClure M et al. 2012 To be annotated To be annotated To be annotated To be annotated P13569-1 [2] Show
255 Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells. Łach A et al. 2012 To be annotated To be annotated To be annotated To be annotated Show
256 Palmitoylation of the sphingosine 1-phosphate receptor S1P is involved in its signaling functions and internalization. Ohno Y et al. 2009 To be annotated To be annotated To be annotated To be annotated P21453 [3] Show
257 Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes. Liu R et al. 2012 To be annotated To be annotated To be annotated To be annotated Show
258 Palmitoylation of MIR2 is required for its function. Anania VG et al. 2011 To be annotated To be annotated To be annotated To be annotated P90489 [1] Show
259 The palmitoylation state of PMP22 modulates epithelial cell morphology and migration. Zoltewicz SJ et al. 2012 To be annotated To be annotated To be annotated To be annotated P16646 [1] Show
261 Reengineering the collision coupling and diffusion mode of the A2A-adenosine receptor: palmitoylation in helix 8 relieves confinement. Keuerleber S et al. 2012 To be annotated To be annotated To be annotated To be annotated Show
262 Melanoregulin is stably targeted to the melanosome membrane by palmitoylation. Wu XS et al. 2012 To be annotated To be annotated To be annotated To be annotated Show
263 Palmitoylation at two cysteine clusters on the C-terminus of GluN2A and GluN2B differentially control synaptic targeting of NMDA receptors. Mattison HA et al. 2012 To be annotated To be annotated To be annotated To be annotated Show
264 Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets. Israels SJ et al. 2010 To be annotated To be annotated To be annotated To be annotated Show
265 Characterization of the self-palmitoylation activity of the transport protein particle component Bet3. Kümmel D et al. 2010 To be annotated To be annotated To be annotated To be annotated Show
635 A role for palmitoylation in the quality control, assembly and secretion of apolipoprotein B. Vilas GL et al. 2004 Rattus norvegicus McA-RH7777 Total cell lysate Cellular localization of substrate by immunofluorescence, Labeling of substrate with [125I]palmitate Show
267 Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells. Aittaleb M et al. 2011 To be annotated To be annotated To be annotated To be annotated Q86VW2-1 [3] Show
268 Differential regulation of two palmitoylation sites in the cytoplasmic tail of the beta1-adrenergic receptor. Zuckerman DM et al. 2011 To be annotated To be annotated To be annotated To be annotated P08588 [3] Show
236 Regulation of galpha i palmitoylation by activation of the 5-hydroxytryptamine-1A receptor. Chen CA et al. 2000 Cricetulus griseus CHO Total membrane Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
233 Synaptobrevin 2 is palmitoylated in synaptic vesicles prepared from adult, but not from embryonic brain. Veit M et al. 2000 Rattus norvegicus Brain Synaptosomal membrane Cleavage of thioester bonds with β-ME, Labeling of substrate with [3H]palmitate Show
771 Palmitoylation on the carboxyl terminus tail is required for the selective regulation of dopamine D2 versus D3 receptors. Zhang X et al. 2016 Homo sapiens HEK293 Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, Point mutation of substrate Show
271 Palmitoylation influences the function and pharmacology of sodium channels. Bosmans F et al. 2011 To be annotated To be annotated To be annotated To be annotated Show
272 Rap2 function requires palmitoylation and recycling endosome localization. Uechi Y et al. 2009 To be annotated To be annotated To be annotated To be annotated Show
273 Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARalpha and transcription at the Hmgcs2 PPRE. Kostiuk MA et al. 2010 To be annotated To be annotated To be annotated To be annotated P54868-1 [2] Show
274 Palmitoylation of human FasL modulates its cell death-inducing function. Guardiola-Serrano F et al. 2010 To be annotated To be annotated To be annotated To be annotated P48023 [1] Show
275 Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth. Stoeck A et al. 2010 To be annotated To be annotated To be annotated To be annotated P35070 [3] Show
276 Presynaptic trafficking of synaptotagmin I is regulated by protein palmitoylation. Kang R et al. 2004 To be annotated To be annotated To be annotated To be annotated P21707 [5], O43581 [3] Show
636 Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling. Noland CL et al. 2015 Escherichia coli (strain B / BL21-DE3) Whole organism Total cell lysate Mass Spectrometry Show
637 Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling. Noland CL et al. 2015 Homo sapiens HEK293T Non-membrane lysate Labeling of substrate with alk16 Show
638 Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking. Kovalenko OV et al. 2004 Homo sapiens A431 Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate Show
639 Exocytic pathway-independent plasma membrane targeting of heterotrimeric G proteins. Takida S et al. 2004 Chlorocebus aethiops COS7 Total cell lysate Labeling of substrate with [3H]palmitate Show
640 Fatty acylation is important but not essential for Saccharomyces cerevisiae RAS function. Deschenes RJ et al. 1987 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) BJ2169 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P01120 [1] Show
641 Membrane association and conformational change of palmitoylated G(o)alpha. Yang S et al. 2001 To be annotated To be annotated To be annotated Cleavage of thioester bonds with DTT, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
642 miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL. Berg V et al. 2015 Homo sapiens Chronic lymphocytic leukemia Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
643 Membrane targeting of L-type calcium channels. Role of palmitoylation in the subcellular localization of the beta2a subunit. Chien AJ et al. 1998 Homo sapiens tsA 201 Total membrane Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Q8VGC3-2 [2] Show
644 N-Myristoylation and betagamma play roles beyond anchorage in the palmitoylation of the G protein alpha(o) subunit. Wang Y et al. 1999 Homo sapiens HEK293 Total membrane Labeling of substrate with [3H]palmitate Show
49 Palmitoylation of apolipoprotein B is required for proper intracellular sorting and transport of cholesteroyl esters and triglycerides. Zhao Y et al. 2000 Rattus norvegicus McA-RH7777 Medium Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [125I]palmitate, Point mutation of substrate P04114 [1], P04114 [1] Show
645 Palmitoylation of apolipoprotein B is required for proper intracellular sorting and transport of cholesteroyl esters and triglycerides. Zhao Y et al. 2000 Homo sapiens Hep-G2 Medium Labeling of substrate with [125I]palmitate Show
646 Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids. Zhao J et al. 1998 Homo sapiens Raji Total cell lysate Cleavage of thioester bonds with NH2OH, Thin-layer chromatography, Labeling of substrate with [3H]palmitate Show
647 Surfactant protein C precursor is palmitoylated and associates with subcellular membranes. Vorbroker DK et al. 1992 Cricetulus griseus CHO Total cell lysate Labeling of substrate with [3H]palmitate Show
648 Nitric oxide modulates beta(2)-adrenergic receptor palmitoylation and signaling. Adam L et al. 1999 Chlorocebus aethiops COS7 Total membrane Labeling of substrate with [3H]palmitate Show
649 Nitric oxide modulates beta(2)-adrenergic receptor palmitoylation and signaling. Adam L et al. 1999 Homo sapiens HEK293 Total membrane Labeling of substrate with [3H]palmitate Show
650 Nitric oxide modulates beta(2)-adrenergic receptor palmitoylation and signaling. Adam L et al. 1999 Spodoptera frugiperda Sf9 Total membrane Labeling of substrate with [3H]palmitate Show
651 Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses. Dejanovic B et al. 2014 Mus musculus Hippocampal neuron Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
652 Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses. Dejanovic B et al. 2014 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Over-expression of palmitoyltransferase, ABE (Acyl-Biotin Exchange) Q03555-4 [2] Show
653 Palmitoylation of the rat mu opioid receptor. Chen C et al. 1998 Chlorocebus aethiops COS7 Total cell lysate Cleavage of thioester bonds with DTT, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Point mutation of substrate, Thin-layer chromatography Show
654 Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus. Brede G et al. 2003 Chlorocebus aethiops COS1 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P11801-1 [1] Show
655 Mechanistic insights into the inhibitory effects of palmitoylation on cytosolic thioredoxin reductase and thioredoxin. Qin H et al. 2015 Homo sapiens Hep-G2 Total cell lysate Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Thiopropyl captivation, Mass Spectrometry P10599-1 [3] Show
656 Differential palmitoylation of two mouse glutamate receptor interacting protein 1 forms with different N-terminal sequences. Yamazaki M et al. 2001 Chlorocebus aethiops COS7 Total membrane Labeling of substrate with [3H]palmitate Show
657 Functional characterization of palmitoylated and nonacylated SNAP-25 purified from insect cells infected with recombinant baculovirus. Kammer B et al. 2003 Spodoptera frugiperda Sf9 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P60881-1 [4] Show
658 Functional implications of post-translational modifications of phospholipases D1 and D2. Xie Z et al. 2002 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Truncation of substrate, Labeling of substrate with [3H]palmitate P70496 [2], P70498 [2] Show
659 A novel palmitoyl acyl transferase controls surface protein palmitoylation and cytotoxicity in Giardia lamblia. Touz MC et al. 2005 Giardia intestinalis Whole organism Total cell lysate Point mutation of substrate, Truncation of substrate, Labeling of substrate with [3H]palmitate Q24992-1 [1] Show
660 Palmitoylation of the 25-kDa synaptosomal protein (SNAP-25) in vitro occurs in the absence of an enzyme, but is stimulated by binding to syntaxin. Veit M 2000 To be annotated To be annotated To be annotated Labeling of substrate with [3H]palmitate Show
83 Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H. Maisse C et al. 2008 To be annotated To be annotated To be annotated To be annotated Q8IZJ1 [1] Show
661 Regulation by cAMP of post-translational processing and subcellular targeting of endothelial nitric-oxide synthase (type 3) in cardiac myocytes. Belhassen L et al. 1997 Rattus norvegicus Ventricular myocytes Total cell lysate Labeling of substrate with [3H]palmitate Show
662 Analysis of the palmitoylation and membrane targeting domain of neuromodulin (GAP-43) by site-specific mutagenesis. Liu Y et al. 1993 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate P06837-1 [2] Show
663 Glycosylation, palmitoylation, and localization of the human D2S receptor in baculovirus-infected insect cells. Grünewald S et al. 1996 Spodoptera frugiperda Sf9 Non-membrane lysate Labeling of substrate with [3H]palmitate Show
388 Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: evidence from palmitoylation and overexpression of G proteins. Stanislaus D et al. 1998 Rattus norvegicus GGH3 Total cell lysate Labeling of substrate with [3H]palmitate Show
111 Identification of G protein alpha subunit-palmitoylating enzyme. Tsutsumi R et al. 2009 Homo sapiens HeLa Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, Cellular localization of palmitoyltransferase by fusion with fluorescent protein, Cellular localization of palmitoyltransferase by immunofluorescence, Cellular localization of substrate by fusion with fluorescent protein, Cellular localization of substrate by immunofluorescence, Depletion of palmitoyltransferase with siRNA, Point mutation of palmitoyltransferase Show
341 B cell signaling is regulated by induced palmitoylation of CD81. Cherukuri A et al. 2004 To be annotated To be annotated To be annotated To be annotated Show
772 Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5. Brigidi GS et al. 2015 Homo sapiens Hippocampal neuron Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of palmitoyltransferase by fusion with fluorescent protein, Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Co-immunoprecipitation of palmitoyltransferase and substrate, Depletion of palmitoyltransferase with shRNA, Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Point mutation of substrate Show
419 Assaying protein palmitoylation in plants. Hemsley PA et al. 2008 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) To be annotated Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Over-expression of palmitoyltransferase, Point mutation of substrate Q52T38 [1] Show
664 Identification of G protein alpha subunit-palmitoylating enzyme. Tsutsumi R et al. 2009 To be annotated To be annotated To be annotated Point mutation of substrate, Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate P50148 [2] Show
665 N-terminal palmitoylation within the appropriate amino acid environment conveys on NOS2 the ability to progress along the intracellular sorting pathways. Navarro-Lérida I et al. 2006 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate P35228 [1] Show
666 The C-terminal end of R-Ras contains a focal adhesion targeting signal. Furuhjelm J et al. 2003 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate P10301 [1] Show
667 Chemical inhibition of myristoylation of the G-protein Gi1 alpha by 2-hydroxymyristate does not interfere with its palmitoylation or membrane association. Evidence that palmitoylation, but not myristoylation, regulates membrane attachment. Galbiati F et al. 1996 Chlorocebus aethiops COS7 Total cell lysate Labeling of substrate with [3H]palmitate Show
668 The juxtamembrane lysine and arginine residues of surfactant protein C precursor influence palmitoylation via effects on trafficking. ten Brinke A et al. 2001 Cricetulus griseus CHO-K1 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate P11686-1 [2] Show
669 The stoichiometry of G alpha(s) palmitoylation in its basal and activated states. Jones TL et al. 1997 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate P63095-1 [1] Show
670 Palmitoylation of human thyrotropin receptor: slower intracellular trafficking of the palmitoylation-defective mutant. Tanaka K et al. 1998 Homo sapiens HEK293 Total membrane Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P16473-1 [1] Show
671 Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling. Holland SM et al. 2016 Homo sapiens HEK293T Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 17-ODYA (17-octadecynoic acid), Point mutation of substrate Q60700 [1] Show
672 Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling. Holland SM et al. 2016 Rattus norvegicus Sensory neurons Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
673 Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Zhou T et al. 2015 Mus musculus Cardiomyocytes Total cell lysate Point mutation of substrate, Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate P61014-1 [1] Show
674 Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Zhou T et al. 2015 To be annotated To be annotated To be annotated Point mutation of substrate, Labeling of substrate with [14C]palmitate P61014-1 [1] Show
675 Covalent binding of fatty acid to the transferrin receptor in cultured human cells. Omary MB et al. 1981 Homo sapiens RPMI-8402 Total cell lysate Cleavage of thioester bonds with NH2OH, Thin-layer chromatography, Labeling of substrate with [3H]palmitate Show
676 Covalent binding of fatty acid to the transferrin receptor in cultured human cells. Omary MB et al. 1981 Homo sapiens CCRF-CEM Total cell lysate Cleavage of thioester bonds with NH2OH, Thin-layer chromatography, Labeling of substrate with [3H]palmitate Show
677 Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization. Alland L et al. 1994 Chlorocebus aethiops COS1 Total membrane Point mutation of substrate, Labeling of substrate with [125I]-IC16 palmitate, Thin-layer chromatography, Labeling of substrate with [3H]palmitate P06241 [2] Show
678 Failure to myristoylate the alpha subunit of Gz is correlated with an inhibition of palmitoylation and membrane attachment, but has no affect on phosphorylation by protein kinase C. Hallak H et al. 1994 Homo sapiens HEK293 Total cell lysate Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Show
679 Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. Clyde-Smith J et al. 2000 Chlorocebus aethiops COS Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
680 A GIPC1-palmitate switch modulates dopamine Drd3 receptor trafficking and signaling. Arango-Lievano M et al. 2016 Cricetulus griseus CHO Non-membrane lysate Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate Show
681 A GIPC1-palmitate switch modulates dopamine Drd3 receptor trafficking and signaling. Arango-Lievano M et al. 2016 Homo sapiens HEK293 Non-membrane lysate ABE (Acyl-Biotin Exchange), Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, Point mutation of substrate P35462-1 [1] Show
682 Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. Benjannet S et al. 2001 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P56818-1 [3] Show
206 Palmitoylation of inducible nitric-oxide synthase at Cys-3 is required for proper intracellular traffic and nitric oxide synthesis. Navarro-Lérida I et al. 2004 Chlorocebus aethiops COS7 Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [125I]palmitate, Labeling of substrate with [3H]palmitate, Point mutation of substrate P29477-1 [1] Show
683 Palmitoylation of inducible nitric-oxide synthase at Cys-3 is required for proper intracellular traffic and nitric oxide synthesis. Navarro-Lérida I et al. 2004 Mus musculus C2C12 Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate Show
684 CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4. Popik W et al. 2004 Homo sapiens BJAB Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [14C]palmitate P01730-1 [2] Show
685 ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment. Suzuki M et al. 2015 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Q8IZ81-1 [2] Show
625 Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3. van't Hof W et al. 1997 Chlorocebus aethiops COS1 Total cell lysate Labeling of substrate with [125I]-IC16 palmitate Show
238 RGS7 is palmitoylated and exists as biochemically distinct forms. Rose JJ et al. 2000 Spodoptera frugiperda Sf9 Total membrane Thin-layer chromatography, Labeling of substrate with [3H]palmitate Show
686 The cysteine-string domain of the secretory vesicle cysteine-string protein is required for membrane targeting. Chamberlain LH et al. 1998 Rattus norvegicus PC12 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
687 The dually acylated NH2-terminal domain of gi1alpha is sufficient to target a green fluorescent protein reporter to caveolin-enriched plasma membrane domains. Palmitoylation of caveolin-1 is required for the recognition of dually acylated g-protein alpha subunits in vivo. Galbiati F et al. 1999 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Truncation of substrate, Labeling of substrate with [3H]palmitate P10824 [1] Show
688 Local palmitoylation cycles define activity-regulated postsynaptic subdomains. Fukata Y et al. 2013 Homo sapiens HEK293T Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Inhibition of palmitoylation with 2-bromopalmitate, Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
689 Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. Roberts PJ et al. 2008 Homo sapiens HEK293T Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
690 rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Debnath J et al. 1999 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate Show
691 Role of the cysteine-rich domain of the t-SNARE component, SYNDET, in membrane binding and subcellular localization. Koticha DK et al. 1999 Mus musculus AtT-20 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Truncation of substrate, Labeling of substrate with [3H]palmitate O09044-1 [4] Show
692 Serotonin-mediated palmitoylation and depalmitoylation of G alpha proteins in rat brain cortical membranes. Bhamre S et al. 1998 Rattus norvegicus Cortical neuron Total membrane Labeling of substrate with [3H]palmitate Show
693 The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: a green fluorescent protein study. Liu J et al. 1997 Mus musculus NIH-3T3 Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Truncation of substrate, Labeling of substrate with [3H]palmitate P29473-1 [1] Show
694 The N-terminal extension of Galphaq is critical for constraining the selectivity of receptor coupling. Kostenis E et al. 1997 Chlorocebus aethiops COS7 Total cell lysate Truncation of substrate, Labeling of substrate with [3H]palmitate Show
695 Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. Charrin S et al. 2002 Homo sapiens Raji Total cell lysate Labeling of substrate with [3H]palmitate Show
696 Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. Charrin S et al. 2002 Homo sapiens HEL Total cell lysate Labeling of substrate with [3H]palmitate Show
773 Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5. Brigidi GS et al. 2015 Homo sapiens HEK293T Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Depletion of palmitoyltransferase with shRNA Show
774 Metabolic labeling of Ras with tritiated palmitate to monitor palmitoylation and depalmitoylation. Tsai FD et al. 2014 Homo sapiens COS1 Total cell lysate Labeling of substrate with [3H]palmitate Show
775 Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome. Moutin E et al. 2016 Mus musculus Hippocampal neuron Total cell lysate Cleavage of thioester bonds with NH2OH, Acyl RAC, Point mutation of palmitoyltransferase, Depletion of palmitoyltransferase with shRNA Show
776 Characterization and partial purification of protein fatty acyltransferase activity from rat liver. Hiol A et al. 2003 Bos taurus liver Plasma Membrane Cleavage of thioester bonds with NH2OH, Inhibition of palmitoyltransferase with drug, Labeling of substrate with [3H]palmitate, Labeling of substrate with [3H]palmitoyl-CoA, Liquid Chromatography Show
777 Characterization and partial purification of protein fatty acyltransferase activity from rat liver. Hiol A et al. 2003 Homo sapiens liver Plasma Membrane Point mutation of substrate, Labeling of substrate with [3H]palmitoyl-CoA, Liquid Chromatography, Labeling of substrate with [3H]palmitate Show
778 Characterization and partial purification of protein fatty acyltransferase activity from rat liver. Hiol A et al. 2003 Mus musculus Sf9 Cytosol Labeling of substrate with [3H]palmitate Show
779 Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif. Zlatkine P et al. 1997 Homo sapiens COS7 Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate Show
780 Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine. Bach R et al. 1988 Homo sapiens HFL1 Total cell lysate Cleavage of thioester bonds with NH2OH, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate Show
782 Acylation of cell-associated IL-1 by palmitic acid. Bakouche O et al. 1991 Homo sapiens To be annotated Plasma Membrane Cleavage of thioester bonds with NH2OH, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate Show
783 Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds. Kaufman JF et al. 1984 Homo sapiens JY Total cell lysate Cleavage of thioester bonds with NH2OH, Thin-layer chromatography, Labeling of substrate with [3H]palmitate, Labeling of substrate with [35S]-Cysteine Show
781 The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence. Follit JA et al. 2010 Mus musculus IMCD3 Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate Show
784 Agonist-modulated palmitoylation of beta 2-adrenergic receptor in Sf9 cells. Mouillac B et al. 1992 Homo sapiens Sf9 Plasma Membrane Labeling of substrate with [3H]palmitate Show
785 A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). Duncan JA et al. 1998 Rattus norvegicus liver Cytosol Labeling of substrate with [3H]palmitoyl-CoA Show
786 A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). Duncan JA et al. 1998 Rattus norvegicus liver Plasma Membrane Labeling of substrate with [3H]palmitoyl-CoA Show
787 A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). Duncan JA et al. 1998 Rattus norvegicus HEK293 Total cell lysate Labeling of substrate with [3H]palmitoyl-CoA, Labeling of substrate with [3H]palmitate Show
788 Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction. Liang X et al. 2001 Homo sapiens COS1 Total cell lysate Labeling of substrate with [125I]palmitate, Labeling of substrate with [3H]palmitate, Mass Spectrometry, Point mutation of substrate, Thin-layer chromatography Show
789 Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling. Osterhout JL et al. 2003 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Show
790 Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling. Osterhout JL et al. 2003 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Show
791 Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue. Hiol A et al. 2003 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Show
792 Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue. Hiol A et al. 2003 Homo sapiens COS7 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate, Labeling of substrate with [35S]-Cysteine Show
793 Assays of protein palmitoylation. Drisdel RC et al. 2006 To be annotated HEK293 To be annotated Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, ABE (Acyl-Biotin Exchange) Show
794 Assays of protein palmitoylation. Drisdel RC et al. 2006 Rattus norvegicus Brain Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, ABE (Acyl-Biotin Exchange) Show
795 Two adjacent cysteine residues in the C-terminal cytoplasmic fragment of bovine rhodopsin are palmitylated. Ovchinnikov YuA et al. 1988 Bos taurus retinae To be annotated Cleavage of thioester bonds with NH2OH, High-Performance Liquid Chromatography (HPLC), Mass Spectrometry, Labeling of substrate with [3H]palmitate Show
796 ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity. Chen B et al. 2016 Homo sapiens HEK293-A Total cell lysate Cleavage of thioester bonds with NH2OH, Co-immunoprecipitation of palmitoyltransferase and substrate, Depletion of palmitoyltransferase with siRNA, Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Point mutation of substrate, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 15-HDYA (15-hexadecynoic acid = alk-14), Mass Spectrometry Show
797 ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity. Chen B et al. 2016 Homo sapiens MDCK Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence Show
798 ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity. Chen B et al. 2016 Homo sapiens MCF-10A Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Depletion of palmitoyltransferase with sgRNA Show
799 Probing protein palmitoylation at the yeast vacuole. Meiringer CT et al. 2006 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) To be annotated Vacuoles ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Labeling of substrate with [3H]palmitoyl-CoA, Point mutation of palmitoyltransferase Show
800 The variant-specific surface protein of Giardia, VSP4A1, is a glycosylated and palmitoylated protein. Papanastasiou P et al. 1997 Giardia intestinalis To be annotated Total cell lysate Cleavage of thioester bonds with NH2OH, Mass Spectrometry, Labeling of substrate with [3H]palmitate Show
801 Cytoplasmic tail length influences fatty acid selection for acylation of viral glycoproteins. Veit M et al. 1996 Influenza C virus (strain C/Johannesburg/1/1966) MDBK Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Labeling of substrate with [35S]-Cysteine, Point mutation of substrate, Thin-layer chromatography Show
802 Cytoplasmic tail length influences fatty acid selection for acylation of viral glycoproteins. Veit M et al. 1996 Influenza A virus (A/udorn/1972(H3N2)) CV-1 Total cell lysate Cellular localization of substrate by immunofluorescence, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate, Labeling of substrate with [35S]-Cysteine Show
803 Acylation of keratinocyte transglutaminase by palmitic and myristic acids in the membrane Anchorage region. Chakravarty R et al. 1989 Homo sapiens To be annotated Total cell lysate Cleavage of thioester bonds with NH2OH, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate Show
804 Palmitylation of the vaccinia virus 37-kDa major envelope antigen. Identification of a conserved acceptor motif and biological relevance. Grosenbach DW et al. 1997 Vaccinia Virus BSC Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Show
805 Site-specific mutagenesis identifies three cysteine residues in the cytoplasmic tail as acylation sites of influenza virus hemagglutinin. Veit M et al. 1991 Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1) CV-1 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Truncation of substrate, Labeling of substrate with [3H]palmitate Show
806 The presence of cysteine in the cytoplasmic domain of the vesicular stomatitis virus glycoprotein is required for palmitate addition. Rose JK et al. 1984 Vesicular Stomatitis Virus COS1 Total cell lysate Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate, Labeling of substrate with [35S]-Cysteine, Point mutation of substrate, Truncation of substrate Show
697 Altered palmitoylation and neuropathological deficits in mice lacking HIP14. Singaraja RR et al. 2011 To be annotated To be annotated To be annotated Cleavage of thioester bonds with NH2OH, Over-expression of palmitoyltransferase, ABE (Acyl-Biotin Exchange) Show
699 Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. Abrami L et al. 2006 Cricetulus griseus CHO Total cell lysate Labeling of substrate with [3H]palmitate Show
700 Palmitoylation supports assembly and function of integrin-tetraspanin complexes. Yang X et al. 2004 Homo sapiens A431 Total cell lysate Labeling of substrate with [3H]palmitate Show
701 Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms. Keith DJ et al. 2012 Rattus norvegicus Hippocampal neuron Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
702 Synaptobrevin 2 is palmitoylated in synaptic vesicles prepared from adult, but not from embryonic brain. Veit M et al. 2000 Rattus norvegicus PC12 Total cell lysate Labeling of substrate with [3H]palmitate Show
703 Involvement of fatty acid synthase in axonal development in mouse embryos. Ueno K 2000 Mus musculus Neuron Total cell lysate Labeling of substrate with [3H]palmitate Show
704 A novel N-terminal motif for palmitoylation of G-protein alpha subunits. Parenti M et al. 1993 Rattus norvegicus PC12 Total membrane Labeling of substrate with [3H]palmitate Show
705 A novel N-terminal motif for palmitoylation of G-protein alpha subunits. Parenti M et al. 1993 To be annotated NG108-15 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
706 A novel N-terminal motif for palmitoylation of G-protein alpha subunits. Parenti M et al. 1993 To be annotated NG108-15 Total cell lysate Labeling of substrate with [3H]palmitate Show
707 A novel N-terminal motif for palmitoylation of G-protein alpha subunits. Parenti M et al. 1993 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P59215 [1] Show
708 Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor. Jang D et al. 2015 Homo sapiens HEK293T Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
270 Palmitoylation of nicotinic acetylcholine receptors. Alexander JK et al. 2010 Torpedo californica Neuron Synaptosomal membrane Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
710 Dynamic palmitoylation of G-protein-coupled receptors in eukaryotic cells. Bouvier M et al. 1995 Spodoptera frugiperda Sf9 Total membrane Labeling of substrate with [3H]palmitate Show
711 Palmitoylation of G-protein alpha subunits. Linder ME et al. 1995 Spodoptera frugiperda Sf9 Total membrane Labeling of substrate with [3H]palmitate Show
712 Palmitoylation of G-protein alpha subunits. Linder ME et al. 1995 Spodoptera frugiperda Sf9 Total cell lysate Labeling of substrate with [3H]palmitate Show
278 Formation of aquaporin-4 arrays is inhibited by palmitoylation of N-terminal cysteine residues. Suzuki H et al. 2008 To be annotated To be annotated To be annotated To be annotated P47863 [2] Show
279 Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Kang R et al. 2008 To be annotated To be annotated To be annotated To be annotated Q8CFN2-2 [2], P31016 [2] Show
281 Characterization of the delta2 glutamate receptor-binding protein delphilin: Splicing variants with differential palmitoylation and an additional PDZ domain. Matsuda K et al. 2006 To be annotated To be annotated To be annotated To be annotated Q0QWG9-2 [1] Show
282 Molecular determinants of activation and membrane targeting of phosphoinositol 4-kinase IIbeta. Jung G et al. 2008 To be annotated To be annotated To be annotated To be annotated Q8TCG2 [4] Show
283 Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region. Di Paolo G et al. 1997 To be annotated To be annotated To be annotated To be annotated P21818 [2] Show
253 Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant. Motoki K et al. 2012 To be annotated To be annotated To be annotated To be annotated Q8IYC8 [4] Show
709 Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding. Agüera-González S et al. 2011 Cricetulus griseus CHO Total cell lysate Point mutation of substrate, Labeling of substrate with 15-Azidopentadecanoic Acid (Click-IT Palmitic Acid) Q29983 [2], G1JTE6 [2] Show
284 Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. Tani M et al. 2007 To be annotated To be annotated To be annotated To be annotated Q9JJY3 [5] Show
285 Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65. Takahashi Y et al. 2009 To be annotated To be annotated To be annotated To be annotated Q16518 [1] Show
286 Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170. Ohta E et al. 2003 To be annotated To be annotated To be annotated To be annotated Q7Z5G4 [2] Show
287 Palmitylation of a G-protein coupled receptor. Direct analysis by tandem mass spectrometry. Papac DI et al. 1992 To be annotated To be annotated To be annotated To be annotated P02699 [2] Show
288 Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Kurayoshi M et al. 2007 To be annotated To be annotated To be annotated To be annotated P22725 [1] Show
289 Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum. Thorne RF et al. 2010 To be annotated To be annotated To be annotated To be annotated P16671 [4] Show
290 Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3. Lam KK et al. 2006 To be annotated To be annotated To be annotated To be annotated Show
291 Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. Tian L et al. 2012 To be annotated To be annotated To be annotated To be annotated Show
292 Palmitoylated TMX and calnexin target to the mitochondria-associated membrane. Lynes EM et al. 2012 To be annotated To be annotated To be annotated To be annotated Q9H3N1 [2] Show
294 Palmitoylation of claudins is required for efficient tight-junction localization. Van Itallie CM et al. 2005 To be annotated To be annotated To be annotated To be annotated O95500 [4] Show
713 A polybasic domain allows nonprenylated Ras proteins to function in Saccharomyces cerevisiae. Mitchell DA et al. 1994 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Point mutation of substrate, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate P01120 [2] Show
179 GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. Fang C et al. 2006 Homo sapiens HEK293T Total cell lysate Cellular localization of palmitoyltransferase by immunofluorescence, Cellular localization of substrate by fusion with fluorescent protein, Co-immunoprecipitation of palmitoyltransferase and substrate, Over-expression of palmitoyltransferase, Point mutation of substrate, Two-hybrid assay with palmitoyltransferase and substrate, Labeling of substrate with [3H]palmitate Show
714 N-terminal fatty acylation of the alpha-subunit of the G-protein Gi1: only the myristoylated protein is a substrate for palmitoylation. Galbiati F et al. 1994 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P10824 [1] Show
715 Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation. Degtyarev MY et al. 1994 Chlorocebus aethiops COS7 Total membrane Point mutation of substrate, Labeling of substrate with [3H]palmitate P10824 [1] Show
716 Palmitoylation of metabotropic glutamate receptor subtype 4 but not 1 alpha expressed in permanently transfected BHK cells. Alaluf S et al. 1995 Mesocricetus auratus BHK Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
717 Assessment of fusogenic properties of influenza virus hemagglutinin deacylated by site-directed mutagenesis and hydroxylamine treatment. Philipp HC et al. 1995 Spodoptera frugiperda Sf9 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
718 Autoacylation of G protein alpha subunits. Duncan JA et al. 1996 To be annotated To be annotated To be annotated Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
297 Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels. Tian L et al. 2008 To be annotated To be annotated To be annotated To be annotated Q9EQ27 [2] Show
298 Acylation of bovine rhodopsin by [3H]palmitic acid. O'Brien PJ et al. 1984 To be annotated To be annotated To be annotated To be annotated Show
327 Site-specific analysis of protein S-acylation by resin-assisted capture. Forrester MT et al. 2011 Homo sapiens HEK293 Total membrane Acyl RAC, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Point mutation of substrate P62280 [1], P60468 [1], O14880 [2], P01112 [2] Show
300 The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain. Greaves J et al. 2011 To be annotated To be annotated To be annotated To be annotated Show
301 Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14. Huang K et al. 2011 To be annotated To be annotated To be annotated To be annotated Show
303 Palmitoylation controls the catalytic activity and subcellular distribution of phosphatidylinositol 4-kinase II{alpha}. Barylko B et al. 2009 To be annotated To be annotated To be annotated To be annotated Q99M64 [3] Show
304 Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling. Feig C et al. 2007 To be annotated To be annotated To be annotated To be annotated P25445 [1] Show
305 DHHC2 is a protein S-acyltransferase for Lck. Zeidman R et al. 2011 To be annotated To be annotated To be annotated To be annotated Show
306 Constitutive Gs-mediated, but not G12-mediated, activity of the 5-hydroxytryptamine 5-HT7(a) receptor is modulated by the palmitoylation of its C-terminal domain. Kvachnina E et al. 2009 To be annotated To be annotated To be annotated To be annotated P32304 [3] Show
307 Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets. Canobbio I et al. 2008 To be annotated To be annotated To be annotated To be annotated P61225 [2] Show
308 Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src. Tsutsumi K et al. 2008 To be annotated To be annotated To be annotated To be annotated Q80YE4-2 [3] Show
309 Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts. Bhattacharyya R et al. 2013 To be annotated To be annotated To be annotated To be annotated P05067 [2] Show
310 Intracellular cysteine residues in the tail of MHC class I proteins are crucial for extracellular recognition by leukocyte Ig-like receptor 1. Gruda R et al. 2007 To be annotated To be annotated To be annotated To be annotated P01889 [2] Show
311 Palmitoylation of the TPbeta isoform of the human thromboxane A2 receptor. Modulation of G protein: effector coupling and modes of receptor internalization. Reid HM et al. 2007 To be annotated To be annotated To be annotated To be annotated P21731-2 [3] Show
312 Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation. Galluzzo P et al. 2007 To be annotated To be annotated To be annotated To be annotated Show
314 Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8. He Y et al. 2009 To be annotated To be annotated To be annotated To be annotated O15400 [1], Q9UNK0 [1] Show
317 Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian cells. Fukata Y et al. 2006 To be annotated To be annotated To be annotated To be annotated P31016 [2], P60881 [3] Show
318 Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. Jia L et al. 2011 To be annotated To be annotated To be annotated To be annotated Show
319 Ara6, a plant-unique novel type Rab GTPase, functions in the endocytic pathway of Arabidopsis thaliana. Ueda T et al. 2001 To be annotated To be annotated To be annotated To be annotated Q9CB01 [1] Show
320 Activation status-coupled transient S acylation determines membrane partitioning of a plant Rho-related GTPase. Sorek N et al. 2007 To be annotated To be annotated To be annotated To be annotated Show
321 Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding. Nishimura A et al. 2013 To be annotated To be annotated To be annotated To be annotated P60766-1 [1], P63321 [1], Q9JIW9 [1], Q9D658 [1] Show
322 Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. Berzat AC et al. 2005 To be annotated To be annotated To be annotated To be annotated Q7L0Q8 [1] Show
323 Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells. Tucker DE et al. 2005 To be annotated To be annotated To be annotated To be annotated Show
324 Bioorthogonal click chemistry to assay mu-opioid receptor palmitoylation using 15-hexadecynoic acid and immunoprecipitation. Ebersole B et al. 2014 To be annotated To be annotated To be annotated To be annotated Show
325 Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. Marin EP et al. 2012 To be annotated To be annotated To be annotated To be annotated P00441 [1] Show
326 A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis. Hemsley PA et al. 2013 To be annotated To be annotated To be annotated To be annotated Q9FL28 [2] Show
328 Proteomic analysis of palmitoylated platelet proteins. Dowal L et al. 2011 To be annotated To be annotated To be annotated To be annotated Q86YW5 [1] Show
420 Assaying protein palmitoylation in plants. Hemsley PA et al. 2008 Arabidopsis thaliana To be annotated To be annotated Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
295 S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. Yount JS et al. 2012 Mus musculus DC2.4 Total cell lysate Cleavage of thioester bonds with NH2OH, Mass Spectrometry, Point mutation of substrate, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Q9CQW9 [3] Show
293 The human and simian immunodeficiency virus envelope glycoprotein transmembrane subunits are palmitoylated. Yang C et al. 1995 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P04578 [2] Show
329 Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23. Ivaldi C et al. 2012 To be annotated To be annotated To be annotated To be annotated P11836 [2], P06734 [2] Show
330 Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3. Merrick BA et al. 2011 To be annotated To be annotated To be annotated To be annotated Q9JIZ9 [5] Show
331 Global analysis of protein palmitoylation in yeast. Roth AF et al. 2006 To be annotated To be annotated To be annotated To be annotated P38085 [1], P48813 [1], P06775 [1], P38084 [1], Q00245 [1] Show
332 Large-scale profiling of protein palmitoylation in mammalian cells. Martin BR et al. 2009 To be annotated To be annotated To be annotated To be annotated Show
336 Subcellular localization of herpes simplex virus type 1 UL51 protein and role of palmitoylation in Golgi apparatus targeting. Nozawa N et al. 2003 To be annotated To be annotated To be annotated To be annotated F8RDF1 [1] Show
338 The role of palmitoylation in functional expression of nicotinic alpha7 receptors. Drisdel RC et al. 2004 To be annotated To be annotated To be annotated To be annotated Show
313 The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function. Pedone KH et al. 2007 Homo sapiens HEK293 Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Point mutation of substrate O95837 [3], P30679 [2] Show
719 Multiple features of the p59fyn src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization. Timson Gauen LK et al. 1996 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate P39688 [2] Show
339 Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. Fragoso R et al. 2003 To be annotated To be annotated To be annotated To be annotated P01730 [2] Show
340 The human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residues. Veit M 2004 To be annotated To be annotated To be annotated To be annotated O15498 [2] Show
343 A palmitoylation switch mechanism regulates Rac1 function and membrane organization. Navarro-Lérida I et al. 2012 To be annotated To be annotated To be annotated To be annotated P63000 [1] Show
344 Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine. Zhai L et al. 2004 To be annotated To be annotated To be annotated To be annotated Show
345 Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Miura GI et al. 2006 To be annotated To be annotated To be annotated To be annotated Q01083 [1] Show
360 Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities. Wang DA et al. 2005 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [14C]palmitate P62745 [2] Show
347 Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting. Canto I et al. 2013 To be annotated To be annotated To be annotated To be annotated P25116 [2] Show
348 Subunit-selective palmitoylation regulates the intracellular trafficking of AMPA receptor. Yang G et al. 2009 To be annotated To be annotated To be annotated To be annotated Show
349 Acylation of CD44 and its association with lipid rafts are required for receptor and hyaluronan endocytosis. Thankamony SP et al. 2006 To be annotated To be annotated To be annotated To be annotated P16070-12 [2] Show
356 Submicromolar concentrations of palmitoyl-CoA specifically thioesterify cysteine 244 in glyceraldehyde-3-phosphate dehydrogenase inhibiting enzyme activity: a novel mechanism potentially underlying fatty acid induced insulin resistance. Yang J et al. 2005 To be annotated To be annotated To be annotated To be annotated P46406 [1] Show
361 Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. Kostiuk MA et al. 2008 To be annotated To be annotated To be annotated To be annotated Show
368 Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting. Robinson LJ et al. 1995 To be annotated To be annotated To be annotated To be annotated Show
335 Control of signalling efficacy by palmitoylation of the rat Y1 receptor. Holliday ND et al. 2003 Cricetulus griseus CHO-K1 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P21555 [1] Show
337 Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae. Dietzen DJ et al. 1995 Canis familiaris MDCK Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P33724 [3] Show
377 Regulation of the Skeletal Muscle Ryanodine Receptor/Ca2+-release Channel RyR1 by S-Palmitoylation. Chaube R et al. 2014 Oryctolagus cuniculus Skeletal muscle Total cell lysate Acyl RAC, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 17-ODYA (17-octadecynoic acid), Liquid Chromatography, Mass Spectrometry P04191 [8], P11716 [18] Show
537 Global Analysis of Palmitoylated Proteins in Toxoplasma gondii. Foe IT et al. 2015 Toxoplasma gondii Whole organism Total membrane Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Labeling of substrate with 17-ODYA (17-octadecynoic acid) B6KAM0 [1] Show
586 Acylation-dependent protein export in Leishmania. Denny PW et al. 2000 Leishmania major Whole organism Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate Q25326-1 [1] Show
376 Synaptobrevin 2 is palmitoylated in synaptic vesicles prepared from adult, but not from embryonic brain. Veit M et al. 2000 Chlorocebus aethiops COS1 Total cell lysate Labeling of substrate with [3H]palmitate Show
371 Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. Fiorentino M et al. 2008 Homo sapiens iPreC Total cell lysate Labeling of substrate with [3H]palmitate Show
373 Distinct Palmitoylation Events at the Amino-terminal Conserved Cysteines of Env7 Direct Its Stability, Localization, and Vacuolar Fusion Regulation in S. cerevisiae. Manandhar SP et al. 2014 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Point mutation of substrate Q12003 [3] Show
375 GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. De Vries L et al. 1996 Chlorocebus aethiops COS7 Total membrane Labeling of substrate with [3H]palmitate Show
366 Involvement of fatty acid synthase in axonal development in mouse embryos. Ueno K 2000 To be annotated To be annotated To be annotated Point mutation of substrate, Thin-layer chromatography, Labeling of substrate with [3H]palmitate P06837 [2] Show
370 A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein. Schweizer A et al. 1993 Chlorocebus aethiops Vero Total cell lysate Labeling of substrate with [3H]palmitate Show
367 Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca(2+)-calmodulin. Yeh DC et al. 1999 Chlorocebus aethiops COS7 Total cell lysate Labeling of substrate with [3H]palmitate, Over-expression of Acyl-Protein Thioesterase Show
365 Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible. Parat MO et al. 2001 Bos taurus BAEC Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Reverse-phase chromatography, Thin-layer chromatography Show
362 Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae. Bartels DJ et al. 1999 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Cellular localization of palmitoyltransferase by immunofluorescence, Knock-out of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
720 Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor. Stanislaus D et al. 1997 Rattus norvegicus pituitary cells Total cell lysate Labeling of substrate with [3H]palmitate Show
357 CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner. Clark KL et al. 2004 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P60033-1 [3] Show
355 Substitution of the cysteine 438 residue in the cytoplasmic tail of the glucagon-like peptide-1 receptor alters signal transduction activity. Vázquez P et al. 2005 Cricetulus griseus CHO-K1 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P32301 [1] Show
354 Carboxyl tail cysteine mutants of the thyrotropin-releasing hormone receptor type 1 exhibit constitutive signaling: role of palmitoylation. Du D et al. 2005 Cricetulus griseus CHO Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P21761 [2] Show
353 Unique self-palmitoylation activity of the transport protein particle component Bet3: a mechanism required for protein stability. Kümmel D et al. 2006 To be annotated To be annotated To be annotated Point mutation of substrate, Labeling of substrate with [3H]palmitoyl-CoA, Inhibition of palmitoylation with 2-bromopalmitate O43617 [1] Show
352 Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o. Takida S et al. 2005 Chlorocebus aethiops COS7 Total cell lysate Labeling of substrate with [3H]palmitate Show
351 Activation of an alpha2A-adrenoceptor-Galphao1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor. Barclay E et al. 2005 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P18871 [1], P59215 [1] Show
350 The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity. Takahashi Y et al. 2006 Homo sapiens HEK293-A Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Q16518 [3] Show
387 Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q). Evanko DS et al. 2000 To be annotated To be annotated To be annotated To be annotated Show
403 Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses. Dejanovic B et al. 2014 Spodoptera frugiperda Sf9 Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Labeling of substrate with 17-ODYA (17-octadecynoic acid), Mass Spectrometry Q03555-4 [2] Show
402 Palmitoylation of plakophilin is required for desmosome assembly. Roberts BJ et al. 2014 Homo sapiens A431 Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 17-ODYA (17-octadecynoic acid), Point mutation of substrate Q9Y446-1 [1], Q99959-2 [1] Show
421 Assaying protein palmitoylation in plants. Hemsley PA et al. 2008 Arabidopsis thaliana Heyn Col-4 ecotype root cell suspension Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
389 Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration. Anilkumar N et al. 2005 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P50281 [1] Show
396 Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules. Ren Q et al. 1998 Chlorocebus aethiops COS7 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Point mutation of substrate, Thin-layer chromatography O94856-5 [1] Show
422 Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase. van de Loo JW et al. 1997 Cricetulus griseus CHO-K1 Total cell lysate Cleavage of thioester bonds with NH2OH, Truncation of substrate, Labeling of substrate with [3H]palmitate Q16549-1 [5] Show
423 Compartmentalization of integrin alpha6beta4 signaling in lipid rafts. Gagnoux-Palacios L et al. 2003 Rattus norvegicus 804 G Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [125I]-IC16 palmitate, Labeling of substrate with [3H]palmitate, Truncation of substrate P16144 [7] Show
424 Compartmentalization of integrin alpha6beta4 signaling in lipid rafts. Gagnoux-Palacios L et al. 2003 Homo sapiens HaCaT Total cell lysate Labeling of substrate with [125I]-IC16 palmitate Show
425 Compartmentalization of integrin alpha6beta4 signaling in lipid rafts. Gagnoux-Palacios L et al. 2003 Homo sapiens HEK293T Total cell lysate Labeling of substrate with [3H]palmitate P16144 [5] Show
404 Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly. He M et al. 2014 Homo sapiens HEK293 Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
399 The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS. Hess DT et al. 1992 Rattus norvegicus retinae Total membrane Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
56 Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor. Crise B et al. 1992 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P01730 [2] Show
383 Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. Charrin S et al. 2002 Cricetulus griseus CHO Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P21926 [6] Show
401 The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. Smotrys JE et al. 2005 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Knock-out of palmitoyltransferase, Labeling of substrate with [3H]palmitate, Labeling of substrate with [3H]palmitoyl-CoA, Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Point mutation of substrate P39968-1 [3] Show
397 DCC association with lipid rafts is required for netrin-1-mediated axon guidance. Hérincs Z et al. 2005 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P43146-1 [1] Show
393 Palmitoylation and its effect on the GTPase-activating activity and conformation of RGS2. Ni J et al. 2006 Escherichia coli (strain K12) Whole organism Total cell lysate Point mutation of substrate, Labeling of substrate with [14C]palmitate P41220 [3] Show
392 Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. Abrami L et al. 2006 Cricetulus griseus CHO Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, Point mutation of substrate Q9H6X2-1 [3] Show
391 LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Zhang W et al. 1998 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate O43561 [2] Show
390 Rho2 palmitoylation is required for plasma membrane localization and proper signaling to the fission yeast cell integrity MAPK pathway. Sánchez-Mir L et al. 2014 Schizosaccharomyces pombe Whole organism Non-membrane lysate ABE (Acyl-Biotin Exchange), Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Over-expression of palmitoyltransferase, Point mutation of substrate Q10133 [1] Show
386 Regulation of RGS3 and RGS10 palmitoylation by GnRH. Castro-Fernández C et al. 2002 Rattus norvegicus GGH3 Total cell lysate Labeling of substrate with [3H]palmitate Show
385 Palmitoylation of the three isoforms of human endothelin-converting enzyme-1. Schweizer A et al. 1999 Cricetulus griseus CHO Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Point mutation of substrate P42892-2 [1], P42892-1 [1], P42892-3 [1] Show
384 Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling. Berditchevski F et al. 2002 Homo sapiens MDA-MB-231 Total cell lysate Cellular localization of substrate by immunofluorescence, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, Point mutation of substrate P48509 [6] Show
382 Palmitoylation supports assembly and function of integrin-tetraspanin complexes. Yang X et al. 2004 Homo sapiens MDA-MB-231 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P16144 [7] Show
381 Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms. Keith DJ et al. 2012 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate P24588-1 [2] Show
380 Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1. Kitamura T et al. 2013 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) P43353 [1] Show
379 Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. Wang YX et al. 1998 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P39968 [0], P39968 [3] Show
378 N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization. Cadwallader KA et al. 1994 Chlorocebus aethiops COS Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P01112 [0], P01112 [2] Show
363 N-terminal palmitoylation is required for Toxoplasma gondii HSP20 inner membrane complex localization. De Napoli MG et al. 2013 Toxoplasma gondii Whole organism Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, Point mutation of substrate Q6DUA8 [3] Show
358 Palmitoyl acyltransferase, zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. Song IW et al. 2014 Homo sapiens HEK293 Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Co-immunoprecipitation of palmitoyltransferase and substrate, Inhibition of palmitoylation with 2-bromopalmitate, Over-expression of palmitoyltransferase, Point mutation of substrate, Truncation of palmitoyltransferase P53690-1 [1] Show
721 CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner. Clark KL et al. 2004 Homo sapiens Jurkat Total cell lysate Labeling of substrate with [3H]palmitate Show
302 S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Fröhlich M et al. 2014 Homo sapiens HEK293 Non-membrane lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Point mutation of substrate, Over-expression of palmitoyltransferase Q07812 [1] Show
413 S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Fröhlich M et al. 2014 Chlorocebus aethiops COS7 Non-membrane lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
414 S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis. Fröhlich M et al. 2014 Spodoptera frugiperda Sf9 Non-membrane lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, ABE (Acyl-Biotin Exchange) Show
415 The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL et al. 2014 Homo sapiens HEK293 Total cell lysate Co-immunoprecipitation of palmitoyltransferase and substrate, Over-expression of palmitoyltransferase, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
212 Cysteine34 of the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sorting. Schweizer A et al. 1996 Mus musculus L Cells Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P11456 [2] Show
426 Fatty acylation of phospholipase D1 on cysteine residues 240 and 241 determines localization on intracellular membranes. Sugars JM et al. 1999 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Q13393-1 [2] Show
427 Interplay between phosphorylation and palmitoylation mediates plasma membrane targeting and sorting of GAP43. Gauthier-Kemper A et al. 2014 Rattus norvegicus PC12 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P07936-1 [2] Show
808 Analysis of the site occupancy constraints of primary amino acid sequences in the motif directing palmitylation of the vaccinia virus 37-kDa envelope protein. Hansen SG et al. 1999 Vaccinia Virus BSC Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
722 Unique self-palmitoylation activity of the transport protein particle component Bet3: a mechanism required for protein stability. Kümmel D et al. 2006 Mesocricetus auratus BHK Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate O43617 [1] Show
416 Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease. Wan J et al. 2013 Mus musculus Brain Total cell lysate ABE (Acyl-Biotin Exchange), Acyl RAC, Cleavage of thioester bonds with NH2OH, Over-expression of palmitoyltransferase, Mass Spectrometry, SILAC Show
418 The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity. Lemonidis K et al. 2014 Homo sapiens HEK293T Total cell lysate Cellular localization of palmitoyltransferase by immunofluorescence, Co-immunoprecipitation of palmitoyltransferase and substrate, Labeling of substrate with [3H]palmitate, Over-expression of palmitoyltransferase Show
732 Palmitoylation regulates the intracellular trafficking and stability of c-Met. Coleman DT et al. 2016 Homo sapiens DU145 Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 15-Azidopentadecanoic Acid (Click-IT Palmitic Acid), Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
417 Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease. Wan J et al. 2013 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
333 Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion. Veit M et al. 2001 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) DKY6281 Vacuoles Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate Show
725 Coupling of endothelin receptors to the ERK/MAP kinase pathway. Roles of palmitoylation and G(alpha)q. Cramer H et al. 2001 Spodoptera frugiperda Sf9 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
726 C-terminal domain of the Epstein-Barr virus LMP2A membrane protein contains a clustering signal. Matskova L et al. 2001 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
727 Polarized targeting of peripheral membrane proteins in neurons. El-Husseini Ael-D et al. 2001 Chlorocebus aethiops COS7 Total cell lysate Labeling of substrate with [3H]palmitate Show
728 Enzymatic depalmitoylation of viral glycoproteins with acyl-protein thioesterase 1 in vitro. Veit M et al. 2001 Mesocricetus auratus BHK Viral fraction Thin-layer chromatography, Labeling of substrate with [3H]palmitate Show
729 Enzymatic depalmitoylation of viral glycoproteins with acyl-protein thioesterase 1 in vitro. Veit M et al. 2001 To be annotated To be annotated To be annotated Thin-layer chromatography, Labeling of substrate with [3H]palmitate, Over-expression of Acyl-Protein Thioesterase Show
730 Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells. Parat MO et al. 2002 Bos taurus BAEC Total cell lysate Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Show
731 Structural requirements for palmitoylation of surfactant protein C precursor. ten Brinke A et al. 2002 Cricetulus griseus CHO Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
733 Palmitoylation regulates the intracellular trafficking and stability of c-Met. Coleman DT et al. 2016 Homo sapiens H1993 Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 15-Azidopentadecanoic Acid (Click-IT Palmitic Acid), Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
734 Palmitoylation regulates the intracellular trafficking and stability of c-Met. Coleman DT et al. 2016 Homo sapiens AU565 Total cell lysate Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
735 Palmitoylation regulates the intracellular trafficking and stability of c-Met. Coleman DT et al. 2016 Homo sapiens HCC1806 Total cell lysate Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
736 Palmitoylation regulates the intracellular trafficking and stability of c-Met. Coleman DT et al. 2016 Homo sapiens MDA-MB-231 Total cell lysate Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
737 Palmitoylation regulates the intracellular trafficking and stability of c-Met. Coleman DT et al. 2016 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
412 ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment. Suzuki M et al. 2015 Homo sapiens Huh-7 Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
738 Whi2 enhances methylmercury toxicity in yeast via inhibition of Akr1 palmitoyltransferase activity. Hwang GW et al. 2016 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) BY4742 Total cell lysate ABE (Acyl-Biotin Exchange), Knock-out of palmitoyltransferase, Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Cleavage of thioester bonds with NH2OH Show
405 Human CLC-K Channels Require Palmitoylation of their Accessory Subunit Barttin to be Functional. Steinke KV et al. 2015 Homo sapiens HEK293 Total cell lysate Labeling of substrate with [3H]palmitate, ABE (Acyl-Biotin Exchange) Q8WZ55 [2] Show
359 Cys-Palmitoylation of the Gamma Subunit has a Dominant Role in Modulating Activity of the Epithelial Sodium Channel. Mukherjee A et al. 2014 Canis familiaris MDCK Total cell lysate Point mutation of substrate, ABE (Acyl-Biotin Exchange) Q9WU39 [2] Show
406 Glut4 palmitoylation at Cys223 plays a critical role in Glut4 membrane trafficking. Ren W et al. 2015 Homo sapiens HEK293 Total cell lysate Labeling of substrate with 17-ODYA (17-octadecynoic acid), Point mutation of substrate, Thiopropyl captivation, Cellular localization of substrate by fusion with fluorescent protein P14672-1 [1] Show
407 New insights into the posttranslational regulation of human cytosolic thioredoxin by S-palmitoylation. Xu Z et al. 2015 Homo sapiens EA.hy 926 Total cell lysate Acyl RAC, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Liquid Chromatography, Mass Spectrometry P10599 [1] Show
408 Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity. George J et al. 2015 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) P53667 [2] Show
409 Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Fredericks GJ et al. 2014 Homo sapiens HEK293 Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Depletion of palmitoyltransferase with shRNA, Inhibition of palmitoylation with 2-bromopalmitate, Point mutation of substrate P29994 [2] Show
411 Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability. Rossin A et al. 2015 Homo sapiens SW480 Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Co-immunoprecipitation of palmitoyltransferase and substrate, Depletion of palmitoyltransferase with siRNA, Point mutation of palmitoyltransferase, Point mutation of substrate P25445-1 [1] Show
266 A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR. Maritzen T et al. 2010 Chlorocebus aethiops COS7 Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
374 Palmitoylation of the Immunity Related GTPase, Irgm1: Impact on Membrane Localization and Ability to Promote Mitochondrial Fission. Henry SC et al. 2014 Homo sapiens 3T3 MEF Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Q60766 [4] Show
410 The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150. Woolfrey KM et al. 2015 Chlorocebus aethiops COS7 Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of palmitoyltransferase by immunofluorescence, Co-immunoprecipitation of palmitoyltransferase and substrate, Point mutation of palmitoyltransferase, Point mutation of substrate Show
809 Platelets possess and require an active protein palmitoylation pathway for agonist-mediated activation and in vivo thrombus formation. Sim DS et al. 2007 Homo sapiens Platelet Total cell lysate Inhibition of palmitoyltransferase with drug, Labeling of substrate with [3H]palmitate Show
810 Expression and characterization of the Ha-ras p21 protein produced at high levels in the insect/baculovirus system. Page MJ et al. 1989 Homo sapiens Sf9 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Labeling of substrate with [35S]-Cysteine Show
811 LMP2A does not require palmitoylation to localize to buoyant complexes or for function. Katzman RB et al. 2004 Epstein-Barr virus (strain B95-8) BJAB Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
813 Persistent membrane association of activated and depalmitoylated G protein alpha subunits. Huang C et al. 1999 Homo sapiens HEK293 Total cell lysate Labeling of substrate with [3H]palmitate Show
807 Freely turning over palmitate in erythrocyte membrane proteins is not responsible for the anchoring of lipid rafts to the spectrin skeleton: a study with bio-orthogonal chemical probes. Ciana A et al. 2013 Homo sapiens erythrocyte Total membrane Acyl RAC, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Inhibition of palmitoyltransferase with drug, Labeling of substrate with alk16 Show
814 Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. Chan P et al. 2016 Homo sapiens MCF-10A Total cell lysate Labeling of substrate with 15-HDYA (15-hexadecynoic acid = alk-14) Show
815 Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. Chan P et al. 2016 Homo sapiens HEK293-A Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with 15-HDYA (15-hexadecynoic acid = alk-14) Show
816 Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. Chan P et al. 2016 To be annotated To be annotated To be annotated Cleavage of thioester bonds with NH2OH, Mass Spectrometry, Labeling of substrate with 15-Hexadecynoyl-CoA, ABE (Acyl-Biotin Exchange) Show
812 Persistent membrane association of activated and depalmitoylated G protein alpha subunits. Huang C et al. 1999 Homo sapiens MA104 Total cell lysate Cellular localization of substrate by immunofluorescence Show
817 Phospholipase A/Acyltransferase enzyme activity of H-rev107 inhibits the H-RAS signaling pathway. Wang CH et al. 2014 Homo sapiens HtTA Total cell lysate Co-immunoprecipitation of palmitoyltransferase and substrate, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
428 Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Impagnatiello MA et al. 2001 Homo sapiens HUVEC Total cell lysate Labeling of substrate with [3H]palmitate Show
430 Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae. Robbins SM et al. 1995 Mus musculus NIH-3T3 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P08631-2 [1] Show
431 Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae. Dong X et al. 2003 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) RJY690 Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Truncation of substrate, Labeling of substrate with [3H]palmitate P01120-1 [1] Show
432 Palmitoylation controls the dynamics of budding-yeast heterochromatin via the telomere-binding protein Rif1. Park S et al. 2011 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) To be annotated To be annotated Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
433 Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Chen MH et al. 2004 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Q62226-1 [1] Show
434 Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Chen MH et al. 2004 Mus musculus MEF Total cell lysate Labeling of substrate with [3H]palmitate Show
435 Palmitoylation of either Cys-3 or Cys-5 is required for the biological activity of the Lck tyrosine protein kinase. Yurchak LK et al. 1995 Rattus norvegicus 208F Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate P06240-1 [2] Show
269 Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding. Agüera-González S et al. 2011 Cricetulus griseus CHO-K1 Total cell lysate To be annotated Show
436 Palmitoylation of nicotinic acetylcholine receptors. Alexander JK et al. 2010 Mus musculus L Cells Total cell lysate Labeling of substrate with [3H]palmitate Show
437 Palmitoylation of nicotinic acetylcholine receptors. Alexander JK et al. 2010 Homo sapiens HEK293 Total cell lysate ABE (Acyl-Biotin Exchange) Show
438 Palmitoylation of POTE family proteins for plasma membrane targeting. Das S et al. 2007 Homo sapiens HEK293T Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
439 Palmitoylation of the GluR6 kainate receptor. Pickering DS et al. 1995 Homo sapiens HEK293 Total membrane Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
440 Palmitoylation of the GluR6 kainate receptor. Pickering DS et al. 1995 Spodoptera frugiperda Sf9 Total membrane Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
441 Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells. Hellewell AL et al. 2014 Homo sapiens YTS NK cells Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) O75558-1 [5] Show
442 Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor. Jang D et al. 2015 Homo sapiens HEK293T Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-fluoropalmitate, ABE (Acyl-Biotin Exchange) Show
443 Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor. Jang D et al. 2015 Homo sapiens HeLa Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
444 A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events. Fraser ID et al. 1998 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate O43687-2 [2] Show
316 Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain. Christgau S et al. 1992 Rattus norvegicus Beta islets homogenates Total membrane Labeling of substrate with [3H]palmitate Show
445 Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D. Eleme K et al. 2004 Homo sapiens Daudi Total cell lysate Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Show
446 Differential fatty acid selection during biosynthetic S-acylation of a transmembrane protein (HEF) and other proteins in insect cells (Sf9) and in mammalian cells (CV1). Reverey H et al. 1996 Spodoptera frugiperda Sf9 Non-membrane lysate Point mutation of substrate, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate P07975-1 [1] Show
447 Differential fatty acid selection during biosynthetic S-acylation of a transmembrane protein (HEF) and other proteins in insect cells (Sf9) and in mammalian cells (CV1). Reverey H et al. 1996 Homo sapiens CV-1 Non-membrane lysate Point mutation of substrate, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate P07975-1 [1] Show
448 Effect of 2-fluoropalmitate, cerulenin and tunicamycin on the palmitoylation and intracellular translocation of myelin proteolipid protein. DeJesus G et al. 2002 Rattus norvegicus Brain To be annotated Labeling of substrate with [3H]palmitoyl-CoA, Inhibition of palmitoylation with 2-fluoropalmitate, Labeling of substrate with [3H]palmitate Show
449 Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species. Liang X et al. 2002 Rattus norvegicus PC12 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Mass Spectrometry Show
450 Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species. Liang X et al. 2002 Chlorocebus aethiops COS1 Total cell lysate Point mutation of substrate, Labeling of substrate with [125I]-IC16 palmitate, Cleavage of thioester bonds with NH2OH, Mass Spectrometry P17677 [2] Show
451 Modification of catalytically active phospholipase D1 with fatty acid in vivo. Manifava M et al. 1999 Chlorocebus aethiops COS Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
452 Palmitoylation of bovine opsin and its cysteine mutants in COS cells. Karnik SS et al. 1993 Chlorocebus aethiops COS1 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P02699-1 [2] Show
260 Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. He M et al. 2012 Canis familiaris MDCK Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate O70511 [1] Show
453 Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. He M et al. 2012 Homo sapiens HEK293 Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Mass Spectrometry, Point mutation of substrate O70511 [1] Show
454 Differential effects of prenylation and s-acylation on type I and II ROPS membrane interaction and function. Sorek N et al. 2011 Mus musculus NIH-3T3 Total cell lysate Mass Spectrometry Show
739 Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin. Dallavilla T et al. 2016 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with siRNA Show
456 Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. Stoffel RH et al. 1994 Spodoptera frugiperda Sf9 Total cell lysate High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate Show
457 Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. Stoffel RH et al. 1994 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate P43250 [3] Show
740 Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia. Pinner AL et al. 2016 Homo sapiens Brain Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
459 Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras. Camp LA et al. 1993 Spodoptera frugiperda Sf9 Total cell lysate Inhibition of thioesterase with drug, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate Show
280 Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. Drenan RM et al. 2005 Homo sapiens HEK293 Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Point mutation of substrate, Thin-layer chromatography Q8BQP9 [2] Show
429 Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain. Christgau S et al. 1992 Spodoptera frugiperda Sf9 Total membrane Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
460 Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP. Song JH et al. 2006 Mus musculus NG108-15 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Q8BQP9-1 [2] Show
461 Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1. Qi D et al. 2014 Nicotiana benthamiana Whole organism Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Q9FE20-1 [2] Show
462 Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1. Qi D et al. 2014 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Q9FE20-1 [2] Show
463 Reversible palmitoylation regulates surface stability of AMPA receptors in the nucleus accumbens in response to cocaine in vivo. Van Dolah DK et al. 2011 Rattus norvegicus Ventral striatum neurons Total cell lysate Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, ABE (Acyl-Biotin Exchange) Show
464 Reversible palmitoylation regulates surface stability of AMPA receptors in the nucleus accumbens in response to cocaine in vivo. Van Dolah DK et al. 2011 Rattus norvegicus Ventral striatum neurons Total cell lysate Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate Show
465 Reversible palmitoylation regulates surface stability of AMPA receptors in the nucleus accumbens in response to cocaine in vivo. Van Dolah DK et al. 2011 Rattus norvegicus Ventral striatum neurons Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
466 S-acylation of the Insulin-Responsive Aminopeptidase (IRAP): Quantitative analysis and Identification of Modified Cysteines. Werno MW et al. 2015 Mus musculus 3T3-L1 Total membrane Cleavage of thioester bonds with NH2OH, Acyl RAC Show
364 Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression. Neumann-Giesen C et al. 2004 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate Q9Z2S9 [3] Show
467 SNAP-25 palmitoylation and plasma membrane targeting require a functional secretory pathway. Gonzalo S et al. 1998 Rattus norvegicus PC12 Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
468 S-palmitoylation and s-oleoylation of rabbit and pig sarcolipin. Montigny C et al. 2014 Oryctolagus cuniculus Skeletal muscle To be annotated Cleavage of thioester bonds with NH2OH, Mass Spectrometry P42532-1 [1] Show
469 Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein. Pan Z et al. 2007 Homo sapiens SU-DHL-16 Total cell lysate Labeling of substrate with [3H]palmitate Show
470 The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities. Heiler S et al. 2015 Homo sapiens HEK293 Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Point mutation of substrate Q9Z1L1-1 [2] Show
471 The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes. Stöckli J et al. 2004 Mus musculus L Cells Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitoyl-CoA P11456-1 [2] Show
472 The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion. Dietrich LE et al. 2004 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) BJ3505 Total cell lysate Labeling of substrate with [3H]palmitate Show
473 The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion. Dietrich LE et al. 2004 To be annotated To be annotated To be annotated Cleavage of thioester bonds with DTT, Labeling of substrate with [3H]palmitate Show
474 Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein. Konitsiotis AD et al. 2015 Homo sapiens HEK293-A Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with 14-PDYA (14-pentadecynoic acid) Q5VTY9-1 [4] Show
475 Agonist-modulated palmitoylation of endothelial nitric oxide synthase. Robinson LJ et al. 1995 Bos taurus BAEC Non-membrane lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
476 Fatty acylation of alpha z. Effects of palmitoylation and myristoylation on alpha z signaling. Wilson PT et al. 1995 Cricetulus griseus CHO-K1 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate F1RLT6-1 [1] Show
477 Palmitoylation of the alpha 2A-adrenergic receptor. Analysis of the sequence requirements for and the dynamic properties of alpha 2A-adrenergic receptor palmitoylation. Kennedy ME et al. 1994 Chlorocebus aethiops COS-M6 Non-membrane lysate Truncation of substrate, Labeling of substrate with [3H]palmitate P18871-1 [1] Show
478 Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. Kennedy ME et al. 1993 Chlorocebus aethiops COS-M6 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P18871-1 [1] Show
479 Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. Kennedy ME et al. 1993 Canis familiaris MDCK-II Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P18871-1 [1] Show
480 Two homologous protein S-acyltransferases, PAT13 and PAT14, cooperatively regulate leaf senescence in Arabidopsis. Lai J et al. 2015 Arabidopsis thaliana To be annotated Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Knock-out of palmitoyltransferase, Acyl RAC Q66GP9 [2] Show
481 Palmitoylation of the glucose transporter in blood-brain barrier capillaries. Pouliot JF et al. 1995 Rattus norvegicus endothelial cells from rat blood-brain barrier capillaries Total cell lysate Cleavage of thioester bonds with KOH, Cleavage of thioester bonds with NH2OH, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate Show
482 Palmitoylation of the cytoplasmic domain of the neural cell adhesion molecule N-CAM serves as an anchor to cellular membranes. Little EB et al. 1998 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate O15394-1 [4] Show
483 Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration. Anilkumar N et al. 2005 Homo sapiens HT-1080 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P50281-1 [1] Show
484 Biochemical characterization of a palmitoyl acyltransferase activity that palmitoylates myristoylated proteins. Berthiaume L et al. 1995 To be annotated To be annotated To be annotated Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [125I]palmitate P06241-1 [2] Show
485 Functional importance of the amino terminus of Gq alpha. Hepler JR et al. 1996 Spodoptera frugiperda Sf9 Total membrane Point mutation of substrate, Truncation of substrate, Labeling of substrate with [3H]palmitate P50148-1 [2] Show
486 Identification of a novel fatty acylated protein that partitions between the plasma membrane and cytosol and is deacylated in response to serum and growth factor stimulation. James G et al. 1989 Mus musculus BC3 H1 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
488 Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting. Robinson LJ et al. 1995 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Truncation of substrate, Labeling of substrate with [3H]palmitate P29473-1 [2] Show
489 Palmitoylation alters protein activity: blockade of G(o) stimulation by GAP-43. Sudo Y et al. 1992 To be annotated To be annotated To be annotated Labeling of substrate with [14C]iodoacetamide treatement, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [14C]palmitate Show
487 Intramembrane translocation and posttranslational palmitoylation of the chloroplast 32-kDa herbicide-binding protein. Mattoo AK et al. 1987 Landoltia punctata Whole organism Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
490 Reversible palmitoylation of the protein-tyrosine kinase p56lck. Paige LA et al. 1993 Mus musculus LSTRA Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
741 Identification of new palmitoylated proteins in Toxoplasma gondii. Caballero MC et al. 2016 Toxoplasma gondii Whole organism Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
514 Chemical identification of cysteine as palmitoylation site in a transmembrane protein (Semliki Forest virus E1). Schmidt M et al. 1988 Mesocricetus auratus BHK-21 Total cell lysate Cleavage of thioester bonds with DTT, Cleavage of thioester bonds with NH2OH, Cleavage of thioester bonds with β-ME, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [14C]iodoacetamide treatement, Labeling of substrate with [3H]palmitate P03315-1 [1] Show
532 The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane. McCallum JF et al. 1995 Chlorocebus aethiops COS1 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P21278 [2] Show
743 Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1). Segal-Salto M et al. 2016 Homo sapiens HEK293 Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
742 Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1). Segal-Salto M et al. 2016 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Over-expression of palmitoyltransferase, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
744 PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. Nakatsu F et al. 2012 Homo sapiens HeLa Total cell lysate Labeling of substrate with alk16 Show
745 Palmitoylated claudin7 captured in glycolipid-enriched membrane microdomains promotes metastasis via associated transmembrane and cytosolic molecules. Thuma F et al. 2016 Rattus norvegicus To be annotated Total cell lysate ABE (Acyl-Biotin Exchange) Show
515 Lipid modifications of G proteins: alpha subunits are palmitoylated. Linder ME et al. 1993 Chlorocebus aethiops COS Total cell lysate Labeling of substrate with [3H]palmitate Show
516 Lipid modifications of G proteins: alpha subunits are palmitoylated. Linder ME et al. 1993 Spodoptera frugiperda Sf9 Total cell lysate High-Performance Liquid Chromatography (HPLC), Reverse-phase chromatography, Labeling of substrate with [3H]palmitate Show
517 Localization of the palmitoylation site in the transmembrane protein p12E of Friend murine leukaemia virus. Hensel J et al. 1995 To be annotated To be annotated To be annotated Cleavage of thioester bonds with NH2OH, High-Performance Liquid Chromatography (HPLC), Mass Spectrometry, Labeling of substrate with [3H]palmitate Show
518 N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4. Topinka JR et al. 1998 Rattus norvegicus Brain Total cell lysate Labeling of substrate with [3H]palmitate Show
519 N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4. Topinka JR et al. 1998 Rattus norvegicus Cerebellar granule cell Total cell lysate Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Show
520 N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4. Topinka JR et al. 1998 Chlorocebus aethiops COS Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P78352 [2] Show
521 Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells. Salom D et al. 2012 Mus musculus eyes Total cell lysate Mass Spectrometry, Liquid Chromatography Q13639 [2] Show
522 Receptor regulation of G-protein palmitoylation. Mumby SM et al. 1994 Chlorocebus aethiops COS-M6 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P59215 [1], P04896 [1] Show
523 Receptor regulation of G-protein palmitoylation. Mumby SM et al. 1994 Spodoptera frugiperda Sf9 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P04896 [1] Show
524 Regulation of mitochondrial carbamoyl-phosphate synthetase 1 activity by active site fatty acylation. Corvi MM et al. 2001 Rattus norvegicus liver Mitochondrion Cleavage of thioester bonds with NH2OH, Labeling of substrate with [125I]palmitate Show
525 Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction. Rodgers W et al. 1994 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P06239 [1] Show
526 Site-directed mutations in the Sindbis virus E2 glycoprotein identify palmitoylation sites and affect virus budding. Ivanova L et al. 1993 Gallus gallus CEF Total membrane Point mutation of substrate, Labeling of substrate with [3H]palmitate P03316 [2] Show
527 The effects of palmitoylation on membrane association of Semliki forest virus RNA capping enzyme. Laakkonen P et al. 1996 Homo sapiens HeLa Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P08411-1 [3] Show
533 The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane. McCallum JF et al. 1995 Chlorocebus aethiops COS1 Total cell lysate Labeling of substrate with [3H]palmitate Show
534 The role of palmitoyl-protein thioesterase in the palmitoylation of endothelial nitric oxide synthase. Michel JB et al. 1997 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P29473 [2] Show
535 The role of palmitoyl-protein thioesterase in the palmitoylation of endothelial nitric oxide synthase. Michel JB et al. 1997 Spodoptera frugiperda Sf9 Total cell lysate Labeling of substrate with [3H]palmitate Show
570 Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. Zhang MM et al. 2013 Schizosaccharomyces pombe Whole organism Total cell lysate Knock-out of palmitoyltransferase, Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
571 Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. Zhang MM et al. 2013 Schizosaccharomyces pombe Whole organism Total cell lysate Knock-out of palmitoyltransferase, Over-expression of palmitoyltransferase, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
572 Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. Zhang MM et al. 2013 Schizosaccharomyces pombe Whole organism Total cell lysate Knock-out of palmitoyltransferase, Over-expression of palmitoyltransferase, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
561 Adenovirus death protein, a transmembrane protein encoded in the E3 region, is palmitoylated at the cytoplasmic tail. Hausmann J et al. 1998 Homo sapiens HeLa Total cell lysate Cleavage of thioester bonds with NH2OH, Cleavage of thioester bonds with β-ME, Labeling of substrate with [3H]palmitate, Point mutation of substrate, Thin-layer chromatography Show
562 Glycosylation and palmitoylation are common modifications of giardia variant surface proteins. Hiltpold A et al. 2000 Giardia intestinalis Whole organism Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
563 Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability. Ebersole B et al. 2015 Homo sapiens HEK293 Total cell lysate Cellular localization of palmitoyltransferase by fusion with fluorescent protein, Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 15-HDYA (15-hexadecynoic acid = alk-14), Point mutation of substrate, Over-expression of palmitoyltransferase P14416-1 [1] Show
564 The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contain multiple S-palmitoylation sites. Itoh M et al. 2015 Homo sapiens HEK293 Total cell lysate Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
565 The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contain multiple S-palmitoylation sites. Itoh M et al. 2015 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) O88703 [5] Show
566 GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. De Vries L et al. 1996 Chlorocebus aethiops COS7 Total membrane Labeling of substrate with [3H]palmitate Show
567 Insulin-regulated protein palmitoylation impacts endothelial cell function. Wei X et al. 2014 Homo sapiens HUVEC Total cell lysate Cleavage of thioester bonds with NH2OH, Mass Spectrometry, ABE (Acyl-Biotin Exchange) Show
568 Insulin-regulated protein palmitoylation impacts endothelial cell function. Wei X et al. 2014 Homo sapiens HUVEC Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
569 Insulin-regulated protein palmitoylation impacts endothelial cell function. Wei X et al. 2014 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, ABE (Acyl-Biotin Exchange) Q61205 [2] Show
573 Quantitative analysis of the human T cell palmitome. Morrison E et al. 2015 Homo sapiens Primary CD4 + T cells Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
574 Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis. Jones ML et al. 2012 Plasmodium falciparum (isolate 3D7) Whole organism Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
575 Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis. Jones ML et al. 2012 Plasmodium falciparum (isolate 3D7) Whole organism Total cell lysate Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
576 Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis. Jones ML et al. 2012 Plasmodium falciparum (isolate 3D7) Whole organism Total cell lysate Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
538 Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Child MA et al. 2013 Toxoplasma gondii Whole organism Total membrane Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
624 Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs. Craven SE et al. 1999 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
747 Palmitoylation regulates the intracellular trafficking and stability of c-Met. Coleman DT et al. 2016 Homo sapiens DU145 To be annotated Labeling of substrate with alk16 Show
587 Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants. Wilson JP et al. 2011 Homo sapiens HEK293T Total cell lysate Labeling of substrate with 15-HDYA (15-hexadecynoic acid = alk-14) Show
531 Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis. Tian N et al. 2012 Mus musculus Cortical neuron Total cell lysate Labeling of substrate with 15-Azidopentadecanoic Acid (Click-IT Palmitic Acid) Show
539 Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting. Fukushima Y et al. 2001 Canis familiaris Sf9 Total cell lysate Labeling of substrate with [3H]palmitoyl-CoA P17124 [1] Show
588 Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants. Wilson JP et al. 2011 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Labeling of substrate with 15-HDYA (15-hexadecynoic acid = alk-14) Q71DI3-1 [1] Show
589 Acylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides. Arnould S et al. 1999 Escherichia coli (strain B / BL21-DE3) Whole organism Total cell lysate Cleavage of thioester bonds with NH2OH, Gas chromatography, Labeling of substrate with [3H]palmitoleic acid, Labeling of substrate with [3H]palmitate Show
590 A cysteine-11 to serine mutant of G alpha12 impairs activation through the thrombin receptor. Ponimaskin E et al. 1998 Spodoptera frugiperda Sf9 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P27600-1 [1] Show
591 Adaptive mutations in Sindbis virus E2 and Ross River virus E1 that allow efficient budding of chimeric viruses. Kim KH et al. 2000 Mesocricetus auratus BHK-21 Viral fraction Point mutation of substrate, Labeling of substrate with [3H]palmitate P08491-1 [1] Show
592 Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling. Druey KM et al. 1999 Chlorocebus aethiops COS7 Total membrane Point mutation of substrate, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate P97428-1 [2] Show
593 Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling. Druey KM et al. 1999 To be annotated To be annotated To be annotated Labeling of substrate with [3H]palmitate Show
594 Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation. Ponimaskin E et al. 2000 Spodoptera frugiperda Sf9 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P27601-1 [3] Show
595 A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans. Barylko B et al. 2001 Chlorocebus aethiops COS7 Total membrane Truncation of substrate, Labeling of substrate with [3H]palmitate Q99M64-1 [4] Show
596 A proline-rich region and nearby cysteine residues target XLalphas to the Golgi complex region. Ugur O et al. 2000 Rattus norvegicus PC12 Total membrane Labeling of substrate with [3H]palmitate Show
617 Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. Webb Y et al. 2000 Chlorocebus aethiops COS Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [125I]-IC16 palmitate, Inhibition of palmitoylation with 2-bromopalmitate Show
618 Interactions of endothelin receptor subtypes A and B with Gi, Go, and Gq in reconstituted phospholipid vesicles. Doi T et al. 1999 Spodoptera frugiperda Sf9 Total membrane Point mutation of substrate, Labeling of substrate with [3H]palmitate P25101 [5], P24530 [4] Show
44 A cell-specific, prenylation-independent mechanism regulates targeting of type II RACs. Lavy M et al. 2002 To be annotated To be annotated To be annotated To be annotated Q9SU67 [2] Show
623 Thioacylation is required for targeting G-protein subunit G(o1alpha) to detergent-insoluble caveolin-containing membrane domains. Guzzi F et al. 2001 Chlorocebus aethiops COS7 Total cell lysate Labeling of substrate with [3H]palmitate Show
746 Palmitoylation regulates the intracellular trafficking and stability of c-Met. Coleman DT et al. 2016 Homo sapiens DU145 Total cell lysate ABE (Acyl-Biotin Exchange) Show
491 Altered phosphorylation and desensitization patterns of a human beta 2-adrenergic receptor lacking the palmitoylated Cys341. Moffett S et al. 1993 Cricetulus griseus CHW Total membrane Labeling of substrate with [3H]palmitate Show
492 Analysis of the posttranslational modifications of the influenza virus M2 protein. Holsinger LJ et al. 1995 Chlorocebus aethiops CV-1 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Q20MD5-1 [1] Show
493 Dual acylation accounts for the localization of {alpha}19-giardin in the ventral flagellum pair of Giardia lamblia. Saric M et al. 2009 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
748 Palmitoylation regulates the intracellular trafficking and stability of c-Met. Coleman DT et al. 2016 Homo sapiens H1993 Total cell lysate Labeling of substrate with alk16 Show
494 Evf, a virulence factor produced by the Drosophila pathogen Erwinia carotovora, is an S-palmitoylated protein with a new fold that binds to lipid vesicles. Quevillon-Cheruel S et al. 2009 Pectobacterium carotovorum subsp. carotovorum Whole organism Total cell lysate Labeling of substrate with [14C]iodoacetamide treatement, Cleavage of thioester bonds with DTT, Mass Spectrometry Q8GCR2-1 [1] Show
495 Inhibition of the receptor-mediated endocytosis of diferric transferrin is associated with the covalent modification of the transferrin receptor with palmitic acid. Alvarez E et al. 1990 Cricetulus griseus CHO Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P02786-1 [2] Show
496 Intrinsic membrane association of the cytoplasmic tail of influenza virus M2 protein and lateral membrane sorting regulated by cholesterol binding and palmitoylation. Thaa B et al. 2011 Cricetulus griseus CHO-K1 Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate Show
497 Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins. Jung V et al. 1995 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Labeling of substrate with [3H]palmitate Show
498 Physiological and biochemical analyses of FlgH, a lipoprotein forming the outer membrane L ring of the flagellar basal body of Salmonella typhimurium. Schoenhals GJ et al. 1996 Escherichia coli (strain B / BL21-DE3) Whole organism Total cell lysate Labeling of substrate with [3H]palmitate Show
499 Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae. Srinivasa SP et al. 1998 Spodoptera frugiperda Sf9 Total membrane Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, High-Performance Liquid Chromatography (HPLC), Labeling of substrate with [3H]palmitate, Point mutation of substrate P49799-1 [2] Show
455 Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification. Horstmeyer A et al. 1996 Spodoptera frugiperda Sf9 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P25101-1 [5] Show
458 Palmitoylation of luteinizing hormone/human choriogonadotropin receptors in transfected cells. Abolition of palmitoylation by mutation of Cys-621 and Cys-622 residues in the cytoplasmic tail increases ligand-induced internalization of the receptor. Kawate N et al. 1994 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P16235-1 [2] Show
500 S-acylation anchors remorin proteins to the plasma membrane but does not primarily determine their localization in membrane microdomains. Konrad SS et al. 2014 Nicotiana benthamiana Leaves Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) H2EST4-1 [1], O23188-1 [1] Show
501 S-acylation of the Insulin-Responsive Aminopeptidase (IRAP): Quantitative analysis and Identification of Modified Cysteines. Werno MW et al. 2015 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Q8C129-1 [2] Show
502 The human and simian immunodeficiency virus envelope glycoprotein transmembrane subunits are palmitoylated. Yang C et al. 1995 Homo sapiens HeLa-T4 Total cell lysate Truncation of substrate, Labeling of substrate with [3H]palmitate Q88018-1 [1] Show
213 Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Yanai A et al. 2006 Rattus norvegicus Cortical neuron Total cell lysate Cellular localization of palmitoyltransferase by immunofluorescence, Cellular localization of substrate by fusion with fluorescent protein, Co-immunoprecipitation of palmitoyltransferase and substrate, Point mutation of substrate, Truncation of substrate P42858 [1] Show
503 Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Yanai A et al. 2006 Chlorocebus aethiops COS Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Truncation of substrate, Labeling of substrate with [3H]palmitate P42858-1 [1] Show
512 Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly. He M et al. 2014 Canis familiaris MDCK Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of palmitoyltransferase by fusion with fluorescent protein, Cellular localization of palmitoyltransferase by immunofluorescence, Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Depletion of palmitoyltransferase with shRNA Show
299 A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44. Babina IS et al. 2014 Homo sapiens MDA-MB-231 Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Point mutation of substrate P16070-12 [2] Show
513 An S-acylation switch of conserved G domain cysteines is required for polarity signaling by ROP GTPases. Sorek N et al. 2010 Arabidopsis thaliana Leaves Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Mass Spectrometry, Gas chromatography Q38912-1 [2] Show
528 SwissPalm: Protein Palmitoylation database. Blanc M et al. 2015 Homo sapiens HeLa Total cell lysate Cleavage of thioester bonds with NH2OH, Thiopropyl captivation, Acyl RAC, Labeling of substrate with [3H]palmitate Show
530 SwissPalm: Protein Palmitoylation database. Blanc M et al. 2015 Homo sapiens HeLa Total cell lysate Acyl RAC Show
749 Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling. Runkle KB et al. 2016 Homo sapiens MDA-MB-231 Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of palmitoyltransferase by immunofluorescence, Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Depletion of palmitoyltransferase with shRNA, Inhibition of palmitoylation with 2-bromopalmitate Show
750 Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling. Runkle KB et al. 2016 Homo sapiens HEK293T Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Mass Spectrometry, Over-expression of palmitoyltransferase, Point mutation of substrate, Truncation of substrate Show
751 Regulation of mitochondrial morphology and function by stearoylation of TFR1. Senyilmaz D et al. 2015 Homo sapiens HeLa Total cell lysate Labeling of substrate with 15-Azidopentadecanoic Acid (Click-IT Palmitic Acid) Show
551 Site-specific attachment of palmitate or stearate to cytoplasmic versus transmembrane cysteines is a common feature of viral spike proteins. Kordyukova LV et al. 2010 Mesocricetus auratus BHK Total membrane Mass Spectrometry Show
552 Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium. Ritter G et al. 1997 Homo sapiens SW1222 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
553 Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium. Ritter G et al. 1997 Homo sapiens COLO205 Total cell lysate Labeling of substrate with [3H]palmitate Show
296 Significance of palmitoylation of CD81 on its association with tetraspanin-enriched microdomains and mediating hepatitis C virus cell entry. Zhu YZ et al. 2012 Homo sapiens Huh-7 Total cell lysate Cellular localization of substrate by immunofluorescence, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, Point mutation of substrate P60033 [8] Show
560 Palmitoylation of the murine leukemia virus envelope glycoprotein transmembrane subunits. Yang C et al. 1996 Homo sapiens HeLa-T4 Total cell lysate Cleavage of thioester bonds with NH2OH, Cleavage of thioester bonds with β-ME, Labeling of substrate with [3H]palmitate, Point mutation of substrate, Thin-layer chromatography O39737-1 [1], O39737-1 [1] Show
597 A shift in protein S-palmitoylation, with persistence of growth-associated substrates, marks a critical period for synaptic plasticity in developing brain. Patterson SI et al. 1999 Rattus norvegicus Cortical neuron Total cell lysate Labeling of substrate with [3H]palmitate Show
598 Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands. Ramulu P et al. 2001 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate G5EBX9-1 [1] Show
599 Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells. Soskic V et al. 1999 Cricetulus griseus CHO Total membrane High-Performance Liquid Chromatography (HPLC), Mass Spectrometry P25023-1 [1] Show
600 Dual fatty acylation of p59(Fyn) is required for association with the T cell receptor zeta chain through phosphotyrosine-Src homology domain-2 interactions. van't Hof W et al. 1999 Chlorocebus aethiops COS1 Total membrane Labeling of substrate with [125I]-IC16 palmitate Show
601 Dual lipid modification of the yeast ggamma subunit Ste18p determines membrane localization of Gbetagamma. Hirschman JE et al. 1999 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P18852-1 [1] Show
602 Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. El-Husseini AE et al. 2000 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate P78352-1 [2] Show
603 Dynamic palmitoylation of neuromodulin (GAP-43) in cultured rat cerebellar neurons and mouse N1E-115 cells. Baker LP et al. 1997 Mus musculus N1E-115 Total cell lysate Cleavage of thioester bonds with DTT, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
604 Dynamic palmitoylation of neuromodulin (GAP-43) in cultured rat cerebellar neurons and mouse N1E-115 cells. Baker LP et al. 1997 Rattus norvegicus Cerebellar granule cell Total cell lysate Labeling of substrate with [3H]palmitate Show
346 Effects of palmitoylation of replicase protein nsP1 on alphavirus infection. Ahola T et al. 2000 Mesocricetus auratus BHK Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate P08411 [3], P03317 [1] Show
605 Enhanced stimulatory adenylyl cyclase signaling during opioid dependence is associated with a reduction in palmitoylated Gs alpha. Ammer H et al. 1997 Homo sapiens A431 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
607 Gsalpha contains an unidentified covalent modification that increases its affinity for adenylyl cyclase. Kleuss C et al. 1997 Spodoptera frugiperda Sf9 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
608 Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors. Higuchi M et al. 2001 Homo sapiens BJAB Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P03230-1 [1] Show
609 Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors. Higuchi M et al. 2001 Homo sapiens BJAB Total cell lysate Labeling of substrate with [3H]palmitate Show
610 Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors. Higuchi M et al. 2001 Homo sapiens HEK293T Total cell lysate Labeling of substrate with [3H]palmitate Show
611 Essential role of CD8 palmitoylation in CD8 coreceptor function. Arcaro A et al. 2000 To be annotated T1.4 hybridomas Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate Show
612 Gbetagamma and palmitate target newly synthesized Galphaz to the plasma membrane. Fishburn CS et al. 1999 Cricetulus griseus CHO-K1 Total cell lysate Labeling of substrate with [3H]palmitate Show
613 Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q). Evanko DS et al. 2000 Homo sapiens HEK293 Total cell lysate Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate Show
614 Direct identification of palmitic acid as the lipid attached to p21ras. Buss JE et al. 1986 Mus musculus NIH-3T3 Total cell lysate Thin-layer chromatography, Labeling of substrate with [3H]palmitate Show
615 Dynamic fatty acylation of p21N-ras. Magee AI et al. 1987 Mus musculus NIH-3T3 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
616 Heterologous expression and characterization of the human R-ras gene product. Lowe DG et al. 1987 Homo sapiens HT-1080 Total cell lysate Labeling of substrate with [3H]palmitate Show
752 27247265 To be annotated To be annotated To be annotated To be annotated Show
753 ZDHHC3 tyrosine phosphorylation regulates NCAM palmitoylation. Lievens PM et al. 2016 Mus musculus Neuro-2a Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
754 ZDHHC3 tyrosine phosphorylation regulates NCAM palmitoylation. Lievens PM et al. 2016 Mus musculus Brain Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
755 ZDHHC3 tyrosine phosphorylation regulates NCAM palmitoylation. Lievens PM et al. 2016 Mus musculus Neuro-2a Total cell lysate Labeling of substrate with 15-Azidopentadecanoic Acid (Click-IT Palmitic Acid) Show
756 TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells. Ra EA et al. 2016 Homo sapiens HeLa To be annotated Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Inhibition of palmitoylation with 2-bromopalmitate Show
554 Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium. Ritter G et al. 1997 Homo sapiens LIM1215 Total cell lysate Labeling of substrate with [3H]palmitate Show
555 Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium. Ritter G et al. 1997 Homo sapiens LIM1215 Total cell lysate Labeling of substrate with [3H]palmitate Show
93 Characterization of palmitoylation of ATP binding cassette transporter G1: effect on protein trafficking and function. Gu HM et al. 2013 Mus musculus J774.1 Total cell lysate Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
581 Chemoproteomics reveals Toll-like receptor fatty acylation. Chesarino NM et al. 2014 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Inhibition of palmitoylation with 2-bromopalmitate, Over-expression of palmitoyltransferase, Labeling of substrate with 17-ODYA (17-octadecynoic acid) O60603 [1], P42082 [1] Show
582 Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Yang W et al. 2010 Homo sapiens DU145 Lipid raft Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
583 5-Hydroxytryptamine 4(a) receptor expressed in Sf9 cells is palmitoylated in an agonist-dependent manner. Ponimaskin EG et al. 2001 Spodoptera frugiperda Sf9 Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Cleavage of thioester bonds with β-ME, Labeling of substrate with [3H]palmitate, Thin-layer chromatography Show
584 A chimeric transmembrane domain directs endothelial nitric-oxide synthase palmitoylation and targeting to plasmalemmal caveolae. Prabhakar P et al. 2000 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P29473-1 [2] Show
585 Activation of the beta(2)-adrenergic receptor-Galpha(s) complex leads to rapid depalmitoylation and inhibition of repalmitoylation of both the receptor and Galpha(s). Loisel TP et al. 1999 Spodoptera frugiperda Sf9 Total membrane Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
621 Requirements and effects of palmitoylation of rat PLD1. Xie Z et al. 2001 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Truncation of substrate, Labeling of substrate with [3H]palmitate P70496 [2] Show
622 RGS7 is palmitoylated and exists as biochemically distinct forms. Rose JJ et al. 2000 Spodoptera frugiperda Sf9 Total membrane Truncation of substrate, Labeling of substrate with [3H]palmitate Show
102 DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Pedram A et al. 2012 Homo sapiens MCF7 Non-nuclear membrane Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with siRNA Show
757 Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. Chan P et al. 2016 Homo sapiens HEK293-A Total cell lysate Labeling of substrate with 15-HDYA (15-hexadecynoic acid = alk-14) Show
541 The alpha-subunits of G-proteins G12 and G13 are palmitoylated, but not amidically myristoylated. Veit M et al. 1994 Spodoptera frugiperda Sf21 Total membrane Cleavage of thioester bonds with NH2OH, Thin-layer chromatography, Labeling of substrate with [3H]palmitate Show
542 Unique regulatory properties of the type 2a Ca2+ channel beta subunit caused by palmitoylation. Qin N et al. 1998 Xenopus laevis oocyte Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
543 Yeast synaptobrevin homologs are modified posttranslationally by the addition of palmitate. Couve A et al. 1995 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P31109-1 [1] Show
544 Cysteine-108 is an acylation site in myelin proteolipid protein. Bizzozero OA et al. 1990 To be annotated To be annotated To be annotated Labeling of substrate with [14C]iodoacetamide treatement, Cleavage of thioester bonds with NH2OH, High-Performance Liquid Chromatography (HPLC), Mass Spectrometry P04116 [1] Show
545 Rapid and transient palmitoylation of the tyrosine kinase Lck mediates Fas signaling. Akimzhanov AM et al. 2015 Homo sapiens Jurkat Total cell lysate Inhibition of thioesterase with drug, Labeling of substrate with 17-ODYA (17-octadecynoic acid), Depletion of palmitoyltransferase with shRNA Show
372 Multiple palmitoylation of synaptotagmin and the t-SNARE SNAP-25. Veit M et al. 1996 Chlorocebus aethiops CV-1 Total membrane Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P60881-1 [4] Show
546 Multiple palmitoylation of synaptotagmin and the t-SNARE SNAP-25. Veit M et al. 1996 Rattus norvegicus PC12 Total membrane Thin-layer chromatography, Labeling of substrate with [3H]palmitate Show
547 Amino-terminal palmitate or polybasic domain can provide required second signal to myristate for membrane binding of p56lck. Kwong J et al. 1995 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Labeling of substrate with [3H]palmitate P06240 [2] Show
548 Fatty acylation of synaptotagmin in PC12 cells and synaptosomes. Chapman ER et al. 1996 Rattus norvegicus Cortical neuron Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
549 Fatty acylation of synaptotagmin in PC12 cells and synaptosomes. Chapman ER et al. 1996 Rattus norvegicus PC12 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
550 Palmitoylation of muscarinic acetylcholine receptor m2 subtypes: reduction in their ability to activate G proteins by mutation of a putative palmitoylation site, cysteine 457, in the carboxyl-terminal tail. Hayashi MK et al. 1997 Spodoptera frugiperda Sf9 Total membrane Point mutation of substrate, Labeling of substrate with [3H]palmitate P08172-1 [1] Show
556 Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium. Ritter G et al. 1997 Homo sapiens SW620 Total cell lysate Labeling of substrate with [3H]palmitate Show
557 Kx, a quantitatively minor protein from human erythrocytes, is palmitoylated in vivo. Carbonnet F et al. 1998 Homo sapiens erythrocyte Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
558 SNAP-23 and SNAP-25 are palmitoylated in vivo. Vogel K et al. 1999 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Truncation of substrate, Labeling of substrate with [3H]palmitate Show
559 SNAP-23 and SNAP-25 are palmitoylated in vivo. Vogel K et al. 1999 Homo sapiens HeLa Total cell lysate Labeling of substrate with [3H]palmitate Show
758 Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells. Boal F et al. 2007 Mesocricetus auratus HIT-T15 To be annotated Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
759 Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. Ohyama T et al. 2007 Drosophila melanogaster Brain Total cell lysate Cellular localization of substrate by immunofluorescence, Cellular localization of palmitoyltransferase by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH Show
760 Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein. Stowers RS et al. 2007 Drosophila melanogaster Whole organism To be annotated Cellular localization of substrate by immunofluorescence, Cellular localization of palmitoyltransferase by fusion with fluorescent protein Show
761 Extensive lipidation of a Torpedo cysteine string protein. Gundersen CB et al. 1994 Xenopus laevis oocyte Plasma Membrane Cleavage of thioester bonds with KOH, Cleavage of thioester bonds with NH2OH, Mass Spectrometry, Labeling of substrate with [3H]palmitoleic acid Show
762 Activation of STING requires palmitoylation at the Golgi. Mukai K et al. 2016 Mus musculus COS1 Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Over-expression of palmitoyltransferase, Point mutation of substrate, Cellular localization of palmitoyltransferase by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate Show
763 Activation of STING requires palmitoylation at the Golgi. Mukai K et al. 2016 Mus musculus MEF Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate Show
764 Activation of STING requires palmitoylation at the Golgi. Mukai K et al. 2016 Mus musculus BMDM Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate Show
765 Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation. Pei Z et al. 2016 Rattus norvegicus Cardiomyocytes To be annotated Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, ABE (Acyl-Biotin Exchange) Show
627 Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation. Bollu LR et al. 2015 Homo sapiens PC3 Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of substrate by immunofluorescence, Inhibition of palmitoyltransferase with drug, Point mutation of substrate, Inhibition of palmitoylation with 2-bromopalmitate P00533 [1] Show
628 Host Cell-catalyzed S-Palmitoylation Mediates Golgi Targeting of the Legionella Ubiquitin Ligase GobX. Lin YH et al. 2015 Chlorocebus aethiops COS1 Golgi apparatus Cellular localization of substrate by fusion with fluorescent protein, Cellular localization of substrate by immunofluorescence, Labeling of substrate with 17-ODYA (17-octadecynoic acid), Point mutation of palmitoyltransferase, Point mutation of substrate, Truncation of substrate, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate Show
629 Host Cell-catalyzed S-Palmitoylation Mediates Golgi Targeting of the Legionella Ubiquitin Ligase GobX. Lin YH et al. 2015 Homo sapiens HEK293T Golgi apparatus Cellular localization of substrate by fusion with fluorescent protein, Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Labeling of substrate with 17-ODYA (17-octadecynoic acid), Point mutation of palmitoyltransferase, Point mutation of substrate, Truncation of substrate, Inhibition of palmitoylation with 2-bromopalmitate Show
630 Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation. Liu KM et al. 2015 Homo sapiens HEK293T Total membrane Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Knock-out of palmitoyltransferase, ABE (Acyl-Biotin Exchange) Q6PCW6 [1] Show
631 Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation. Veluthakal R et al. 2015 Bos taurus retinae Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate Show
55 CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails. Tao N et al. 1996 To be annotated To be annotated To be annotated To be annotated P16671 [4] Show
22 Galpha12 requires acylation for its transforming activity. Jones TL et al. 1998 To be annotated To be annotated To be annotated To be annotated P27600 [1] Show
126 Palmitoylation regulates 17β-estradiol-induced estrogen receptor-α degradation and transcriptional activity. La Rosa P et al. 2012 Homo sapiens MCF7 Nucleus Point mutation of substrate, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate Show
144 Identification of PSD-95 palmitoylating enzymes. Fukata M et al. 2004 Chlorocebus aethiops COS7 Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Q62108 [2] Show
79 Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases. Levy AD et al. 2011 To be annotated To be annotated To be annotated To be annotated P21818 [2] Show
31 A highly conserved cytoplasmic cysteine residue in the α4 nicotinic acetylcholine receptor is palmitoylated and regulates protein expression. Amici SA et al. 2012 Homo sapiens tsA 201 Total cell lysate Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Truncation of substrate P09483 [1] Show
43 Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. Valdez-Taubas J et al. 2005 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) BY4742 Total cell lysate Cleavage of thioester bonds with NH2OH, Knock-out of palmitoyltransferase P31109 [1] Show
18 DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Pedram A et al. 2012 Cricetulus griseus CHO-K1 Non-nuclear membrane Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH P19785 [1] Show
45 Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function. Singaraja RR et al. 2009 Homo sapiens HEK293 Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Cleavage of thioester bonds with KOH, Labeling of substrate with [125I]palmitate O95477 [4] Show
36 Palmitoylation sites and processing of synaptotagmin I, the putative calcium sensor for neurosecretion. Heindel U et al. 2003 Chlorocebus aethiops CV-1 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P21707 [5] Show
33 Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling. Oddi S et al. 2012 Homo sapiens HEK293 Plasma Membrane Point mutation of substrate, ABE (Acyl-Biotin Exchange) P21554 [1] Show
29 Characterization of the palmitoylation domain of SNAP-25. Lane SR et al. 1997 To be annotated To be annotated To be annotated To be annotated P60879 [4] Show
27 Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Chamoun Z et al. 2001 To be annotated To be annotated To be annotated To be annotated Show
32 Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits. Zeng FY et al. 1996 To be annotated To be annotated To be annotated To be annotated P08290 [1], P07306 [1], P02706 [1] Show
30 Wnt proteins are lipid-modified and can act as stem cell growth factors. Willert K et al. 2003 To be annotated To be annotated To be annotated To be annotated P27467 [1] Show
41 Akr1p-dependent palmitoylation of Yck2p yeast casein kinase 1 is necessary and sufficient for plasma membrane targeting. Babu P et al. 2004 To be annotated To be annotated To be annotated To be annotated P23292 [2] Show
48 Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8. Delint-Ramirez I et al. 2011 To be annotated To be annotated To be annotated To be annotated P24588 [2] Show
23 Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. Wedegaertner PB et al. 1993 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P63095 [1], P21279 [2] Show
47 Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. O'Dowd BF et al. 1989 Cricetulus griseus CHW-1102 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P07550 [1] Show
17 Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease. Huang K et al. 2010 Chlorocebus aethiops COS Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, Point mutation of substrate P31596 [1] Show
39 Dual lipid modification motifs in G(alpha) and G(gamma) subunits are required for full activity of the pheromone response pathway in Saccharomyces cerevisiae. Manahan CL et al. 2000 To be annotated To be annotated To be annotated To be annotated P18852 [2], P08539 [1] Show
626 Protein S-acyltransferase 14: a specific role for palmitoylation in leaf senescence in Arabidopsis. Li Y et al. 2015 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Whole organism Total cell lysate Cellular localization of palmitoyltransferase by fusion with fluorescent protein, Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Knock-out of palmitoyltransferase, Point mutation of palmitoyltransferase, Point mutation of substrate Q8VYP5 [1] Show
19 Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins. Shenoy-Scaria AM et al. 1993 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P06240 [2] Show
21 Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association. Wolven A et al. 1997 Chlorocebus aethiops NIH-3T3 Total cell lysate Point mutation of substrate, Labeling of substrate with [125I]-IC16 palmitate P06241 [2] Show
25 Differential functions of phospholipid binding and palmitoylation of tumour suppressor EWI2/PGRL. He B et al. 2011 To be annotated NIH-3T3 To be annotated Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Q969P0 [2] Show
26 Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. Hundt M et al. 2009 Mus musculus Jurkat Plasma Membrane Point mutation of substrate Show
28 Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Chen MH et al. 2004 Mus musculus HEK293 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
34 Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. Shi Y et al. 1994 Mus musculus COS7 Total cell lysate Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Point mutation of substrate Q05683 [2] Show
766 Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation. Pei Z et al. 2016 Homo sapiens HEK293 Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate, Point mutation of substrate Show
37 Palmitoylation of the vasopressin V1a receptor reveals different conformational requirements for signaling, agonist-induced receptor phosphorylation, and sequestration. Hawtin SR et al. 2001 To be annotated To be annotated To be annotated To be annotated P30560 [2] Show
35 The G protein alpha s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification. Degtyarev MY et al. 1993 To be annotated To be annotated To be annotated To be annotated P63095 [1] Show
68 Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Botham A et al. 2011 Cricetulus griseus Pro5 CHO Total cell lysate Cellular localization of substrate by immunofluorescence P55085 [1] Show
51 Palmitoylated calnexin is a key component of the ribosome-translocon complex. Lakkaraju AK et al. 2012 Homo sapiens HeLa Total cell lysate Cellular localization of substrate by immunofluorescence, Co-immunoprecipitation of palmitoyltransferase and substrate, Cleavage of thioester bonds with NH2OH, Over-expression of palmitoyltransferase, Depletion of palmitoyltransferase with shRNA, Depletion of palmitoyltransferase with siRNA P27824 [2] Show
46 Characterization of palmitoylation of ATP binding cassette transporter G1: effect on protein trafficking and function. Gu HM et al. 2013 Homo sapiens HEK293 Total cell lysate Labeling of substrate with 15-HDYA (15-hexadecynoic acid = alk-14) P45844 [5] Show
75 DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. Swarthout JT et al. 2005 To be annotated To be annotated To be annotated Point mutation of substrate, Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate P01112 [2], P01111 [1] Show
82 Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association. Shum L et al. 1996 Homo sapiens To be annotated To be annotated To be annotated P01135 [2] Show
59 Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. Bhattacharyya R et al. 2000 To be annotated To be annotated To be annotated To be annotated Q14344 [2] Show
77 Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10. Tu Y et al. 1999 To be annotated To be annotated To be annotated To be annotated P49799 [3], O43665 [1] Show
78 Post-translational modifications of p21rho proteins. Adamson P et al. 1992 To be annotated To be annotated To be annotated To be annotated P62745 [2] Show
54 Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology. Yang X et al. 2002 To be annotated To be annotated To be annotated To be annotated P48509 [4] Show
42 Long-chain base kinase Lcb4 Is anchored to the membrane through its palmitoylation by Akr1. Kihara A et al. 2005 To be annotated To be annotated To be annotated To be annotated Q12246 [2] Show
52 Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking. Kalinina EV et al. 2003 To be annotated To be annotated To be annotated To be annotated Q90240 [3] Show
57 Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor. Jin H et al. 1999 To be annotated To be annotated To be annotated To be annotated P21728 [2] Show
58 Palmitoylation of human endothelinB. Its critical role in G protein coupling and a differential requirement for the cytoplasmic tail by G protein subtypes. Okamoto Y et al. 1997 To be annotated To be annotated To be annotated To be annotated P24530 [3] Show
64 P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage. Fujimoto T et al. 1993 To be annotated To be annotated To be annotated To be annotated P16109 [1] Show
65 STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins. Gory-Fauré S et al. 2006 To be annotated To be annotated To be annotated To be annotated Q14BB9 [3] Show
66 Recycling of MUC1 is dependent on its palmitoylation. Kinlough CL et al. 2006 To be annotated To be annotated To be annotated To be annotated P15941 [2] Show
63 Evidence that palmitoylation of carboxyl terminus cysteine residues of the human luteinizing hormone receptor regulates postendocytic processing. Munshi UM et al. 2005 To be annotated To be annotated To be annotated To be annotated P22888 [2] Show
72 Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups. Curstedt T et al. 1990 To be annotated To be annotated To be annotated To be annotated P15785 [2], P11686 [2] Show
61 The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence. Gubitosi-Klug RA et al. 2005 To be annotated To be annotated To be annotated To be annotated Q09470 [1] Show
71 The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. Tulloch LB et al. 2011 To be annotated To be annotated To be annotated To be annotated O08589 [1], O00168 [2] Show
85 Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling. Doubravska L et al. 2011 To be annotated To be annotated To be annotated To be annotated Show
81 Identification of the intermolecular disulfide bonds of the human transferrin receptor and its lipid-attachment site. Jing SQ et al. 1987 To be annotated To be annotated To be annotated To be annotated P02786 [1] Show
74 Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes. Dudler T et al. 1996 To be annotated To be annotated To be annotated To be annotated P01112 [2] Show
84 Palmitoylation of the V2 vasopressin receptor. Sadeghi HM et al. 1997 To be annotated To be annotated To be annotated To be annotated P30518 [2] Show
76 An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Rocks O et al. 2005 To be annotated To be annotated To be annotated To be annotated Show
80 Cysteine 29 is the major palmitoylation site on stomatin. Snyers L et al. 1999 To be annotated To be annotated To be annotated To be annotated P27105 [2] Show
88 Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells. Tsukamoto T et al. 2013 Mus musculus Osteoblast-like MC3T3-E1 Total cell lysate Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 17-ODYA (17-octadecynoic acid) O88728 [3] Show
87 DHHC8-Dependent PICK1 Palmitoylation is Required for Induction of Cerebellar Long-Term Synaptic Depression. Thomas GM et al. 2013 Homo sapiens HEK293T Total cell lysate Co-immunoprecipitation of palmitoyltransferase and substrate, ABE (Acyl-Biotin Exchange) Q62083 [1] Show
89 DHHC8-Dependent PICK1 Palmitoylation is Required for Induction of Cerebellar Long-Term Synaptic Depression. Thomas GM et al. 2013 Mus musculus Purkinje neuron Total cell lysate Co-immunoprecipitation of palmitoyltransferase and substrate, ABE (Acyl-Biotin Exchange), Depletion of palmitoyltransferase with shRNA Q62083 [1] Show
92 DHHC8-Dependent PICK1 Palmitoylation is Required for Induction of Cerebellar Long-Term Synaptic Depression. Thomas GM et al. 2013 Rattus norvegicus Neuron Total cell lysate ABE (Acyl-Biotin Exchange) Show
100 DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. Li Y et al. 2012 Mus musculus Neural stem cell To be annotated Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 17-ODYA (17-octadecynoic acid), ABE (Acyl-Biotin Exchange) Show
101 Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. Valdez-Taubas J et al. 2005 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) BY4742 Total cell lysate ABE (Acyl-Biotin Exchange), Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Knock-out of palmitoyltransferase Show
60 Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha. Claudinon J et al. 2009 Homo sapiens L Cells Total cell lysate Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate P17181 [1] Show
70 Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. Miggin SM et al. 2003 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P43119 [2] Show
53 Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways. Blanpain C et al. 2001 Cricetulus griseus CHO-K1 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P51681 [3] Show
103 DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Pedram A et al. 2012 Homo sapiens LNCaP C4-2 Non-nuclear membrane Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with siRNA Show
105 Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Thomas GM et al. 2012 Homo sapiens HEK293T Non-membrane lysate ABE (Acyl-Biotin Exchange), Truncation of palmitoyltransferase, Point mutation of palmitoyltransferase, Depletion of palmitoyltransferase with shRNA Q925T6-2 [1] Show
106 Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Thomas GM et al. 2012 Rattus norvegicus Hippocampal neuron Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange), Depletion of palmitoyltransferase with shRNA Q925T6-2 [1] Show
107 Phosphatidylinositol 4-kinase IIα is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner. Lu D et al. 2012 Homo sapiens HEK293 To be annotated Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
108 Phosphatidylinositol 4-kinase IIα is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner. Lu D et al. 2012 Chlorocebus aethiops COS7 To be annotated Co-immunoprecipitation of palmitoyltransferase and substrate, Over-expression of palmitoyltransferase, Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
109 Phosphatidylinositol 4-kinase IIα is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner. Lu D et al. 2012 Homo sapiens HeLa Total cell lysate Cellular localization of substrate by fusion with fluorescent protein, Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with siRNA Show
113 DHHC17 Palmitoylates ClipR-59 and Modulates ClipR-59 Association with the Plasma Membrane. Ren W et al. 2013 Homo sapiens HEK293 Total cell lysate Co-immunoprecipitation of palmitoyltransferase and substrate, Over-expression of palmitoyltransferase, Thiopropyl captivation, Labeling of substrate with [3H]palmitate Q96DZ5 [2] Show
114 DHHC17 Palmitoylates ClipR-59 and Modulates ClipR-59 Association with the Plasma Membrane. Ren W et al. 2013 Homo sapiens HEK293 Total cell lysate Thiopropyl captivation Show
115 DHHC17 Palmitoylates ClipR-59 and Modulates ClipR-59 Association with the Plasma Membrane. Ren W et al. 2013 Chlorocebus aethiops COS7 Total cell lysate Cellular localization of substrate by immunofluorescence, Co-immunoprecipitation of palmitoyltransferase and substrate, Co-precipitation of palmitoyltransferase and substrate, Over-expression of palmitoyltransferase, Depletion of palmitoyltransferase with shRNA, Labeling of substrate with [3H]palmitate Show
116 DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. Li Y et al. 2012 Mus musculus Neural stem cell Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 17-ODYA (17-octadecynoic acid), ABE (Acyl-Biotin Exchange) Show
117 DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. Li Y et al. 2012 Chlorocebus aethiops COS1 To be annotated Point mutation of palmitoyltransferase, ABE (Acyl-Biotin Exchange) Q14254 [2] Show
120 Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3. Yount JS et al. 2010 Homo sapiens HeLa Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Q01628 [3] Show
121 Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. Kokkola T et al. 2011 Homo sapiens HEK293 Total membrane ABE (Acyl-Biotin Exchange), Depletion of palmitoyltransferase with siRNA, Cellular localization of palmitoyltransferase by fusion with fluorescent protein, Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Point mutation of substrate O08858-1 [1] Show
122 DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation. Wang J et al. 2010 Homo sapiens HEK293 Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with 17-ODYA (17-octadecynoic acid), Co-immunoprecipitation of palmitoyltransferase and substrate, Cleavage of thioester bonds with DTT, Cleavage of thioester bonds with NH2OH P49798 [1] Show
123 Palmitoylation controls recycling in lysosomal sorting and trafficking. McCormick PJ et al. 2008 Homo sapiens HeLa Total cell lysate Inhibition of palmitoylation with 2-fluoropalmitate, Co-immunoprecipitation of palmitoyltransferase and substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Q99523 [1] Show
124 Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box. Baumgart F et al. 2010 Chlorocebus aethiops COS7 To be annotated Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with shRNA Show
125 DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. Swarthout JT et al. 2005 To be annotated To be annotated To be annotated Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
91 Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization. van de Loo JW et al. 2000 Cricetulus griseus CHO-K1 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Q16549 [2] Show
90 Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors. Gao Z et al. 1999 Cricetulus griseus CHO-K1 Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
127 Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43. Skene JH et al. 1989 Rattus norvegicus Neuronal growth cone Total membrane Labeling of substrate with [14C]iodoacetamide treatement, Cleavage of thioester bonds with NH2OH P07936 [2] Show
128 Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae. Shenoy-Scaria AM et al. 1994 Homo sapiens HeLa Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, Cellular localization of substrate by immunofluorescence, Point mutation of substrate P39688 [1] Show
129 Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae. Shenoy-Scaria AM et al. 1994 Homo sapiens HeLa Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
40 The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. Roth AF et al. 2002 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Isogenic LRB759 To be annotated Cleavage of thioester bonds with β-ME, Point mutation of palmitoyltransferase, Point mutation of substrate, Labeling of substrate with [3H]palmitoyl-CoA P23292 [2] Show
132 Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. Huang K et al. 2004 To be annotated To be annotated To be annotated Labeling of substrate with [3H]palmitoyl-CoA, Over-expression of palmitoyltransferase Show
133 Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases. Greaves J et al. 2010 Homo sapiens HEK293T Total cell lysate Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
134 Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases. Greaves J et al. 2010 Homo sapiens HEK293T Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
135 Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity. Huang K et al. 2009 Chlorocebus aethiops COS To be annotated ABE (Acyl-Biotin Exchange) Show
136 Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity. Huang K et al. 2009 Rattus norvegicus Cortical neuron To be annotated ABE (Acyl-Biotin Exchange), Depletion of palmitoyltransferase with siRNA Show
137 Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4. Sharma C et al. 2012 Homo sapiens HEK293 Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with siRNA Show
138 Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4. Sharma C et al. 2012 Homo sapiens PC3 Total cell lysate Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with shRNA Show
139 Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4. Sharma C et al. 2012 Homo sapiens MDA-MB-231 Total cell lysate Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with shRNA Show
142 Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. Greaves J et al. 2008 Homo sapiens HEK293 Total cell lysate Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
143 Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. Greaves J et al. 2008 Rattus norvegicus PC12 To be annotated Labeling of substrate with [3H]palmitate Show
145 Identification of PSD-95 palmitoylating enzymes. Fukata M et al. 2004 Homo sapiens HEK293 Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Cleavage of thioester bonds with DTT, Cleavage of thioester bonds with NH2OH, Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate Q62108 [2] Show
146 Identification of PSD-95 palmitoylating enzymes. Fukata M et al. 2004 Homo sapiens HEK293 Total cell lysate Labeling of substrate with [3H]palmitoyl-CoA, Inhibition of palmitoylation with 2-bromopalmitate, Over-expression of palmitoyltransferase Show
147 Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. Mill P et al. 2009 Homo sapiens HEK293 To be annotated Cellular localization of palmitoyltransferase by immunofluorescence, Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
148 Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. Mill P et al. 2009 Homo sapiens HEK293 To be annotated Point mutation of substrate, Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
110 Identification of G protein alpha subunit-palmitoylating enzyme. Tsutsumi R et al. 2009 Homo sapiens HEK293T Total cell lysate Cleavage of thioester bonds with NH2OH, Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Point mutation of substrate, Labeling of substrate with [3H]palmitate P50148 [2] Show
112 Identification of G protein alpha subunit-palmitoylating enzyme. Tsutsumi R et al. 2009 Homo sapiens HEK293T Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
149 DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151. Sharma C et al. 2008 Homo sapiens HEK293 To be annotated Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with siRNA, Cellular localization of palmitoyltransferase by fusion with fluorescent protein Show
150 DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151. Sharma C et al. 2008 Homo sapiens A431 To be annotated Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
67 Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. Shmueli A et al. 2010 Homo sapiens HEK293 To be annotated Over-expression of palmitoyltransferase Q9NXR1 [1], Q9GZM8 [1] Show
151 Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. Shmueli A et al. 2010 Mus musculus Cortical neuron To be annotated Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
152 Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. Shmueli A et al. 2010 Homo sapiens HEK293 To be annotated Cleavage of thioester bonds with NH2OH, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
153 Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. Shmueli A et al. 2010 Mus musculus Cortical neuron To be annotated Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
154 Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method. Zhang J et al. 2008 Homo sapiens HeLa To be annotated Cellular localization of substrate by immunofluorescence, PICA (Palmitoyl-cysteine Isolation Capture and Analysis), Depletion of palmitoyltransferase with siRNA Show
155 Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method. Zhang J et al. 2008 Chlorocebus aethiops COS To be annotated Cleavage of thioester bonds with NH2OH, Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
156 Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. Noritake J et al. 2009 Rattus norvegicus Hippocampal neuron To be annotated ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with β-ME, Over-expression of dominant-negative palmitoyltransferase, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
24 Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Hayashi T et al. 2005 Homo sapiens HEK293T Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P23818 [1], P23819 [1], Q9Z2W9 [1], Q9Z2W8 [1] Show
157 Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Hayashi T et al. 2005 Homo sapiens HEK293T Total cell lysate Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase P23818 [1], P23819 [1] Show
158 Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts. Gonnord P et al. 2009 Homo sapiens HEK293 Total cell lysate Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, Labeling of substrate with [3H]palmitate Q9Z1M0 [6] Show
159 Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts. Gonnord P et al. 2009 Mus musculus Primary peritoneal macrophage Total cell lysate Labeling of substrate with [3H]palmitate Show
161 Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function. Singaraja RR et al. 2009 Homo sapiens Flp-In-293 Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
140 Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. Fernández-Hernando C et al. 2006 Homo sapiens HEK293 Total cell lysate Over-expression of palmitoyltransferase P29474 [2] Show
141 Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. Fernández-Hernando C et al. 2006 Homo sapiens EA.hy 926 Total cell lysate Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with siRNA Show
163 Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. Hayashi T et al. 2009 Homo sapiens HEK293T Total cell lysate Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
164 Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. Hayashi T et al. 2009 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Q00960 [3], Q00959 [3] Show
166 Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. Ponimaskin E et al. 2008 Mus musculus Neuro-2a Total cell lysate Cleavage of thioester bonds with NH2OH, Cleavage of thioester bonds with β-ME, Labeling of substrate with [3H]palmitate Show
169 Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Takemoto-Kimura S et al. 2007 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Q91VB2 [4] Show
170 Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Takemoto-Kimura S et al. 2007 Chlorocebus aethiops COS7 Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
171 Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. Vetrivel KS et al. 2009 Mus musculus MEF Total cell lysate Point mutation of palmitoyltransferase, Labeling of substrate with [3H]palmitate P56818 [1] Show
172 Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. Vetrivel KS et al. 2009 Mus musculus Neuro-2a Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P56818 [4] Show
173 Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. Vetrivel KS et al. 2009 Chlorocebus aethiops COS7 Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
165 Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. Hayashi T et al. 2009 Rattus norvegicus Cortical neuron Total cell lysate Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate, ABE (Acyl-Biotin Exchange) Show
174 Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Mukai J et al. 2008 Homo sapiens HEK293 To be annotated Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Point mutation of substrate, Labeling of substrate with [3H]palmitate Q62108 [2] Show
175 Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Mukai J et al. 2008 Mus musculus Hippocampal neuron To be annotated Knock-out of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
176 Dual role of the cysteine-string domain in membrane binding and palmitoylation-dependent sorting of the molecular chaperone cysteine-string protein. Greaves J et al. 2006 Rattus norvegicus PC12 Plasma Membrane Cellular localization of substrate by fusion with fluorescent protein, Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, Point mutation of substrate, Truncation of substrate, Labeling of substrate with [3H]palmitate Q29455 [4] Show
177 Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. Saleem AN et al. 2010 Homo sapiens HEK293T To be annotated Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, ABE (Acyl-Biotin Exchange) Show
178 GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. Fang C et al. 2006 Homo sapiens HEK293T Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Cellular localization of palmitoyltransferase by immunofluorescence, Cellular localization of substrate by fusion with fluorescent protein, Over-expression of palmitoyltransferase, Point mutation of substrate, Labeling of substrate with [3H]palmitate, Two-hybrid assay with palmitoyltransferase and substrate Show
182 Multiple palmitoyltransferases are required for palmitoylation-dependent regulation of large conductance calcium- and voltage-activated potassium channels. Tian L et al. 2010 Homo sapiens HEK293 Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Co-immunoprecipitation of palmitoyltransferase and substrate, Over-expression of palmitoyltransferase, Point mutation of substrate, Truncation of substrate, Labeling of substrate with [3H]palmitate, Depletion of palmitoyltransferase with siRNA Q9EQ27 [2] Show
38 Partial constitutive activation of pheromone responses by a palmitoylation-site mutant of a G protein alpha subunit in yeast. Song J et al. 1996 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) YGS5 To be annotated Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate P08539 [1] Show
183 Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors. Gao Z et al. 1999 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P30542 [1] Show
185 Determination of the structural requirements for palmitoylation of p63. Schweizer A et al. 1995 Chlorocebus aethiops COS Total cell lysate Point mutation of substrate, Truncation of substrate, Labeling of substrate with [3H]palmitate Q07065 [1] Show
186 The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279. Barker PA et al. 1994 Rattus norvegicus PC12 Total cell lysate Labeling of substrate with [3H]palmitate Show
187 The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279. Barker PA et al. 1994 Rattus norvegicus PCNA Total cell lysate Cleavage of thioester bonds with β-ME, Cleavage of thioester bonds with DTT, Cleavage of thioester bonds with NH2OH, Labeling of substrate with [3H]palmitate Show
188 The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279. Barker PA et al. 1994 Chlorocebus aethiops COS7 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate P07174 [1] Show
189 CLIPR-59 is a lipid raft-associated protein containing a cytoskeleton-associated protein glycine-rich domain (CAP-Gly) that perturbs microtubule dynamics. Lallemand-Breitenbach V et al. 2004 Homo sapiens HeLa Total cell lysate Inhibition of palmitoylation with 2-bromopalmitate, Cellular localization of substrate by fusion with fluorescent protein, Point mutation of substrate, Truncation of substrate, Labeling of substrate with [3H]palmitate Q96DZ5 [2] Show
190 Palmitoylation is required for efficient Fas cell death signaling. Chakrabandhu K et al. 2007 Homo sapiens HEK293 Total cell lysate Inhibition of palmitoylation with 13-oxypalmitate, Cleavage of thioester bonds with KOH, Point mutation of substrate, Labeling of substrate with [3H]palmitate P25446 [1], P25445 [1] Show
131 Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. Huang K et al. 2004 Chlorocebus aethiops COS Total cell lysate Truncation of palmitoyltransferase, Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
167 Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. Ponimaskin E et al. 2008 Homo sapiens HEK293 Total cell lysate Truncation of substrate, Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
168 Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. Ponimaskin E et al. 2008 Mus musculus Neuro-2a Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
180 Interplay of palmitoylation and phosphorylation in the trafficking and localization of phosphodiesterase 10A: implications for the treatment of schizophrenia. Charych EI et al. 2010 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Q9Y233-2 [1] Show
181 Interplay of palmitoylation and phosphorylation in the trafficking and localization of phosphodiesterase 10A: implications for the treatment of schizophrenia. Charych EI et al. 2010 Homo sapiens HEK293 Total cell lysate Over-expression of palmitoyltransferase, Labeling of substrate with [3H]palmitate Show
191 Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling. Oddi S et al. 2012 Rattus norvegicus Brain Total membrane Labeling of substrate with [3H]palmitoyl-CoA, Cleavage of thioester bonds with NH2OH Show
193 Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling. Zheng H et al. 2012 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) P33535 [1] Show
192 Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channel. Mueller GM et al. 2010 Canis familiaris MDCK Total cell lysate Point mutation of substrate, ABE (Acyl-Biotin Exchange) Q9WU38 [2] Show
69 Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection. Sardjono CT et al. 2006 To be annotated To be annotated To be annotated To be annotated P16284 [1] Show
50 Palmitoylation of cysteine 69 from the COOH-terminal of band 3 protein in the human erythrocyte membrane. Acylation occurs in the middle of the consensus sequence of F--I-IICLAVL found in band 3 protein and G2 protein of Rift Valley fever virus. Okubo K et al. 1991 To be annotated To be annotated To be annotated Cleavage of thioester bonds with NH2OH, Truncation of substrate, Mass Spectrometry P02730 [1] Show
823 Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function. Kaur I et al. 2016 Mus musculus COS Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
824 Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function. Kaur I et al. 2016 Mus musculus Hippocampal neuron Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
825 Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function. Kaur I et al. 2016 Mus musculus Hippocampal neuron Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Inhibition of palmitoylation with 2-bromopalmitate Show
826 Potentiation of Surface Stability of AMPA Receptors by Sulfhydryl Compounds: A Redox-Independent Effect by Disrupting Palmitoylation. Han J et al. 2016 Rattus norvegicus Brain Total cell lysate ABE (Acyl-Biotin Exchange) Show
827 Detecting N-myristoylation and S-acylation of host and pathogen proteins in plants using click chemistry. Boyle PC et al. 2016 Arabidopsis thaliana To be annotated Total cell lysate Labeling of substrate with 15-HDYA (15-hexadecynoic acid = alk-14) Show
828 Detecting N-myristoylation and S-acylation of host and pathogen proteins in plants using click chemistry. Boyle PC et al. 2016 Solanum lycopersicum To be annotated Total cell lysate Labeling of substrate with 13-alkyne Myristic acid ( =alk12 ) Show
767 Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation. Pei Z et al. 2016 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Inhibition of palmitoylation with 2-bromopalmitate, ABE (Acyl-Biotin Exchange) Show
768 Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition. Hernandez JL et al. 2016 Homo sapiens MCF-10A Total cell lysate ABE (Acyl-Biotin Exchange), Cleavage of thioester bonds with NH2OH, Labeling of substrate with 17-ODYA (17-octadecynoic acid), Mass Spectrometry, SILAC Show
769 The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins. De Mazière AM et al. 2002 Homo sapiens HEK293T Total cell lysate Labeling of substrate with [3H]palmitate Show
770 The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins. De Mazière AM et al. 2002 Homo sapiens SK-MEL-3 Total cell lysate Labeling of substrate with [3H]palmitate Show
818 Identification of dually acylated proteins from complementary DNA resources by cell-free and cellular metabolic labeling. Moriya K et al. 2016 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
819 Identification of dually acylated proteins from complementary DNA resources by cell-free and cellular metabolic labeling. Moriya K et al. 2016 Homo sapiens HEK293T Total cell lysate Labeling of substrate with [3H]palmitate Show
820 Identification of dually acylated proteins from complementary DNA resources by cell-free and cellular metabolic labeling. Moriya K et al. 2016 Homo sapiens COS1 Total cell lysate Point mutation of substrate, Cellular localization of substrate by immunofluorescence, Inhibition of palmitoylation with 2-bromopalmitate Show
821 Identification of dually acylated proteins from complementary DNA resources by cell-free and cellular metabolic labeling. Moriya K et al. 2016 Homo sapiens COS1 To be annotated Cellular localization of substrate by immunofluorescence Show
822 S-Acylation of the cellulose synthase complex is essential for its plasma membrane localization. Kumar M et al. 2016 Arabidopsis thaliana To be annotated Total cell lysate Point mutation of substrate, Cellular localization of substrate by fusion with fluorescent protein, Cleavage of thioester bonds with NH2OH, Acyl RAC, ABE (Acyl-Biotin Exchange) Show
830 The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Meyer-Schaller N et al. 2009 Homo sapiens HeLa Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
831 Palmitoylation of caspase-6 by HIP14 regulates its activation. Skotte NH et al. 2016 Cercopithecus aethiops COS7 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Point mutation of palmitoyltransferase, ABE (Acyl-Biotin Exchange) Show
832 S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. Aramsangtienchai P et al. 2017 Homo sapiens HEK293T Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Over-expression of palmitoyltransferase, Point mutation of palmitoyltransferase, Depletion of palmitoyltransferase with shRNA, azido-palmitate (C14N3) Show
833 S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. Aramsangtienchai P et al. 2017 Homo sapiens Jurkat Total cell lysate azido-palmitate (C14N3) Show
834 S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. Aramsangtienchai P et al. 2017 Homo sapiens HUVEC Total cell lysate azido-palmitate (C14N3) Show
835 S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. Aramsangtienchai P et al. 2017 Homo sapiens A-549 Total cell lysate Depletion of palmitoyltransferase with shRNA, azido-palmitate (C14N3) Show
836 S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects. Antinone SE et al. 2017 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Acyl RAC Show
837 DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation. Du K et al. 2017 To be annotated To be annotated To be annotated To be annotated Show
838 Detection of S-Acylated CD95 by Acyl-Biotin Exchange. Rossin A et al. 2017 Homo sapiens Jurkat Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
839 Detection of S-Acylated CD95 by Acyl-Biotin Exchange. Rossin A et al. 2017 Homo sapiens SW480 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
840 Detection of S-Acylated CD95 by Acyl-Biotin Exchange. Rossin A et al. 2017 Homo sapiens HEK293 Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
841 The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs. Zhang Y et al. 2016 Drosophila melanogaster S2 Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
842 S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects. Antinone SE et al. 2017 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Acyl RAC Show
843 S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects. Antinone SE et al. 2017 Homo sapiens HEK293 Total cell lysate Cleavage of thioester bonds with NH2OH, Acyl RAC Show
844 S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects. Antinone SE et al. 2017 Homo sapiens Human spinal chord To be annotated Cleavage of thioester bonds with NH2OH, Acyl RAC Show
845 Specific Palmitoyltransferases Associate with and Activate the Epithelial Sodium Channel. Mukherjee A et al. 2017 Mus musculus HEK293T Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
846 Detection of S-Acylated CD95 by Acyl-Biotin Exchange. Rossin A et al. 2017 Homo sapiens HCT15 Total cell lysate Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
847 Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis. Fang J et al. 2016 Xenopus laevis oocyte Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Acyl RAC, Point mutation of palmitoyltransferase Show
848 A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. Diez-Ardanuy C et al. 2017 Homo sapiens PC12 Total cell lysate To be annotated Show
849 A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. Diez-Ardanuy C et al. 2017 Homo sapiens HEK293T Total cell lysate Labeling of substrate with 15-Azidopentadecanoic Acid (Click-IT Palmitic Acid) Show
851 Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model. Bagh MB et al. 2017 Homo sapiens HEK293 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
850 Palmitoylation regulates glutamate receptor distributions in postsynaptic densities through control of PSD95 conformation and orientation. Jeyifous O et al. 2016 Rattus norvegicus HEK293 Total cell lysate Point mutation of substrate, Co-immunoprecipitation of palmitoyltransferase and substrate, Cleavage of thioester bonds with NH2OH, Labeling of substrate with 17-ODYA (17-octadecynoic acid), ABE (Acyl-Biotin Exchange), over expression of substrate, inhibition of thioesterase with palmostatin B Show
852 Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover. Roberts BJ et al. 2016 Homo sapiens A431 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange), Acyl PEG Exchange (APE) Show
853 Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization. Murphy J et al. 2016 Mus musculus retinae Total cell lysate Cleavage of thioester bonds with NH2OH, Acyl RAC Show
854 Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization. Murphy J et al. 2016 Mus musculus retinae Total cell lysate Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
856 Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice. Kilpatrick CL et al. 2016 Mus musculus HEK293T Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, ABE (Acyl-Biotin Exchange) Show
857 Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization. Murphy J et al. 2016 Homo sapiens RPE-1 Total cell lysate Point mutation of substrate, Cleavage of thioester bonds with NH2OH, Acyl RAC, Labeling of substrate with 17-ODYA (17-octadecynoic acid) Show
863 LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation. Hur EM et al. 2003 Mus musculus HEK293T Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Show
862 Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation. Liu Y et al. 2015 Homo sapiens BJAB Total cell lysate Point mutation of substrate, Labeling of substrate with [3H]palmitate Show