Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.
Belongs to the protease inhibitor I47 (latexin) family.
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.
-Cysteine summary and predictions
Pos in alignment
Isoform 1 [Main isoform]
Cys70 3.71 -1.0870114
Cys144 1.433 -0.51970757
From top to bottom: Cysteine position, CSS-Palm 4.0 score, PalmPred score
Color code for cysteine position:
Predicted (high confidence prediction with CSS-Palm or/and PalmPred) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
Color code for CSS-Palm 4.0: High confidence,
Color code for PalmPred: High confidence (score > 0.4),
Medium confidence (0.1 > score > 0.4),
Low confidence (score < 0.1),