Protein-cysteine N-palmitoyltransferase Rasp EC 2.3.1.- Protein central missing Protein sightless Protein skinny hedgehog
UniProt gene names
rasp, cmn, sit, ski, CG11495
Refseq protein ID
UniProt secondary AC
Isoform 1 (main): 500 aa
Known functions (from UniProt)
Belongs to the membrane-bound acyltransferase family. HHAT subfamily.
Required in hedgehog (hh) expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. Acts within the secretory pathway to catalyze N-terminal palmitoylation of Hh; this lipid modification is required for the embryonic and larval patterning activities of the Hh signal. Not required for Wg signaling.
From top to bottom: Cysteine position, CSS-Palm 4.0 score, PalmPred score
Color code for cysteine position:
Predicted (high confidence prediction with CSS-Palm or/and PalmPred) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
Color code for CSS-Palm 4.0: High confidence,
Color code for PalmPred: High confidence (score > 0.4),
Medium confidence (0.1 > score > 0.4),
Low confidence (score < 0.1),