Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity (By similarity).
Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5.
Probably cycles through vesicles between Golgi and endosomes.
The longin domain regulates palmitoylation and membrane targeting.
Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting (By similarity).
Farnesylation is required for Golgi targeting.
Belongs to the synaptobrevin family.
Contains 1 longin domain.
Contains 1 v-SNARE coiled-coil homology domain.
-Cysteine summary and predictions
Pos in alignment
Isoform 1 [Main isoform]
Cys66 2.114 -1.0231613
Cys194 9.385 0.0
Cys195 14.784 0.0
From top to bottom: Cysteine position, CSS-Palm 4.0 score, PalmPred score
Color code for cysteine position:
Predicted (high confidence prediction with CSS-Palm or/and PalmPred) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
Color code for CSS-Palm 4.0: High confidence,
Color code for PalmPred: High confidence (score > 0.4),
Medium confidence (0.1 > score > 0.4),
Low confidence (score < 0.1),
GO:3919591 Metabolic process GO:3919592 Protein transport GO:3919577 Vesicle targeting GO:3919573 Er to golgi vesicle-mediated transport GO:3919561 Exocytosis GO:3919609 Retrograde transport, endosome to golgi GO:3919578 Vesicle docking involved in exocytosis GO:3919581 Vesicle fusion