Palmitoylation summaryValidated by 2 independant techniques or by a targeted study.
0/1rat palmitoyl-proteome article0orthologues in palmitoyl-proteomes2targeted studies0orthologues in targeted studies2sitesCys22, Cys24Predicted2cysteines in main isoform
Protein general information
UniProt names and subcellular location Protein identifiers Protein names Subcellular locations Stathmin-2
Superior cervical ganglion-10 protein
Source Identifiers UniProt gene names Stmn2, Scg10, Scgn10 IPI ID IPI00326596, IPI00190960 Refseq protein ID NP_445892.1 RGD ID 68947 Ensembl protein ENSRNOP00000015720 Ensembl gene ENSRNOG00000011705 UniProt AC P21818 UniProt ID STMN2_RAT UniProt secondary AC Q9ERH2 Protein length Isoform 1 (main): 179 aa Known functions (from UniProt) N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity). Belongs to the stathmin family. Contains 1 SLD (stathmin-like) domain. Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. Interacts with ITM2C (By similarity). Interacts with MAPK8. Interacts with KIF1BP (By similarity). Interacts (via the N-terminal region) with CIB1 (via C-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the neurite outgrowth inhibition of STMN2 (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia (By similarity). Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons. Expressed in neurons (at protein level). Present in growth cones and abundant in developing neurons. In the developing cerebellum, maximal levels occur at postnatal day 7 and correlate with the onset of neuronal differentiation. By nerve growth factor. Sumoylated. Pphosphorylated by MAPK9 and MAPK10 in the developing brain cortex (By similarity). Phosphorylated mostly by MAPK8.
Cysteine summary and predictions
Pos in alignment 22 24 Topology U U Disulfide no no SS prediction H C SS UniProt NA NA Isoform 1
Topology U Undefined E Extracellular/Lumenal T Transmembrane C Cytosolic/Nuclear Prediction scores From top to bottom: Cysteine position, CSS-Palm 4.0 score, PalmPred score
Color code for cysteine position: Predicted (high confidence prediction with CSS-Palm or/and PalmPred) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
Color code for CSS-Palm 4.0: High confidence, Medium confidence, Low confidence, Not predicted.
Color code for PalmPred: High confidence (score > 0.4), Medium confidence (0.1 > score > 0.4), Low confidence (score < 0.1), Not predicted.
Feature type Isoform 1 phosphorylation 50, 62, 73, 97
UniProt AC UniProt ID Orthology source Organism Gene names Description Isoforms # palmitome articles # targeted studies # of distinct techniques # of known sites Predicted P55821 STMN2_MOUSE OrthoDB, Ensembl, InParanoid Mouse Stmn2, Scg10, Scgn10, Stmb2 Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) 1 0/8 0 0 0 Yes Q93045 STMN2_HUMAN OrthoDB, OMA, Ensembl, InParanoid Human STMN2, SCG10, SCGN10 Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) 2 0/15 0 0 0 Yes Q3MHJ8 Q3MHJ8_BOVIN OrthoDB, OMA, Ensembl Cow STMN2 Stathmin 1 0/0 0 0 0 Yes E7FE68 E7FE68_DANRE OrthoDB, OMA, Ensembl Zebrafish stmn2a Stathmin 1 0/0 0 0 0 Yes E2RQ62 E2RQ62_CANLF OrthoDB Dog STMN4 Stathmin 1 0/0 0 0 0 Yes Q545S4 Q545S4_MOUSE OMA Mouse Stmn2, mCG_10137 Stathmin 1 0/8 0 0 0 Yes F6XCB0 F6XCB0_CANLF OMA, Ensembl Dog STMN2 Stathmin 1 0/0 0 0 0 Yes Q90987 STMN2_CHICK OrthoDB Chicken STMN2, SCG10 Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) 1 0/0 0 0 0 Yes F1PC52 F1PC52_CANLF OrthoDB Dog STMN3 Stathmin 1 0/0 0 0 0 Yes Q6DUB7 STMN1_PIG OrthoDB Pig STMN1 Stathmin 1 0/0 0 0 0 No Q4VBT7 Q4VBT7_DANRE Ensembl Zebrafish stmn2b, stmn2 Stathmin 1 0/0 0 0 0 Yes
Biological process Cellular component Molecular function GO:3596739 Cellular response to nerve growth factor stimulus
GO:6258035 Neuron projection development
GO:6258037 Regulation of cytoskeleton organization
GO:1610674 Negative regulation of neuron projection development
GO:1610659 Positive regulation of neuron projection development
GO:6258018 Microtubule depolymerization
GO:1610691 Positive regulation of microtubule depolymerization
GO:1610637 Negative regulation of microtubule depolymerization
GO:1610684 Negative regulation of microtubule polymerization
GO:3596736 Neuronal cell body
GO:3596735 Neuron projection
GO:1610681 Growth cone
GO:1610636 Golgi apparatus
GO:1610698 Perinuclear region of cytoplasm
GO:1610623 Protein binding
GO:3596738 Calcium-dependent protein binding
GO:6258033 Tubulin binding
Palmitoylation hits and sites
Hit ID Study # Reference Hit list Isoform # Sites (ID, position, characterisation techniques) SPalmH:10334 Study 1 - - SPalmS:389 , Cys22(uncertain) SPalmS:390 , Cys24(uncertain) SPalmH:10341 Study 2 - - SPalmS:403 , Cys22 SPalmS:404 , Cys24