Acyl-protein thioesterase 1 APT-1 EC 3.1.2.- Lysophospholipase 1 Lysophospholipase I LPL-I LysoPLA I
UniProt gene names
Refseq protein ID
Isoform 1 (main): 230 aa
Known functions (from UniProt)
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity).
Palmitoyl-protein + H(2)O = palmitate + protein.
Ubiquitous. Detected at low levels in all tissues tested.
Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
From top to bottom: Cysteine position, CSS-Palm 4.0 score, PalmPred score
Color code for cysteine position:
Predicted (high confidence prediction with CSS-Palm or/and PalmPred) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
Color code for CSS-Palm 4.0: High confidence,
Color code for PalmPred: High confidence (score > 0.4),
Medium confidence (0.1 > score > 0.4),
Low confidence (score < 0.1),