Liprin-alpha-4 Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4 PTPRF-interacting protein alpha-4 Fragment
UniProt gene names
Refseq protein ID
Isoform 1 (main): 1043 aa
Known functions (from UniProt)
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity).
Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Binds RIMS1, RIMS2, GIT1, KIF1A and GRIP1.
Colocalizes with PTPRF at the cell surface.
The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS (By similarity).
Belongs to the liprin family. Liprin-alpha subfamily.
Contains 3 SAM (sterile alpha motif) domains.
-Cysteine summary and predictions
Pos in alignment
Isoform 1 [Main isoform]
Cys194 1.647 -1.0231613
Cys557 4.856 0.0
Cys711 3.302 0.0
Cys827 5.037 0.0
Cys863 3.272 0.0
From top to bottom: Cysteine position, CSS-Palm 4.0 score, PalmPred score
Color code for cysteine position:
Predicted (high confidence prediction with CSS-Palm or/and PalmPred) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
Color code for CSS-Palm 4.0: High confidence,
Color code for PalmPred: High confidence (score > 0.4),
Medium confidence (0.1 > score > 0.4),
Low confidence (score < 0.1),
GO:6226673 Synapse GO:1439286 Cell surface GO:6226674 Presynaptic active zone GO:1439281 Cytoplasm