Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
Schwann cells of the peripheral nervous system.
Specifically expressed at growth arrest of mammalian cells.
A defect in Pmp-22 is the cause of trembler (tr) phenotype. Trembler mice show a Schwann cells defect characterized by severe hypomyelination and continuing Schwann cells proliferation throughout life.
Belongs to the PMP-22/EMP/MP20 family.
-Cysteine summary and predictions
Pos in alignment
Isoform 1 [Main isoform]
Cys42 7.094 -1.0231613
Cys53 0.813 0.0
Cys85 2.829 0.0
Cys109 1.178 0.0
From top to bottom: Cysteine position, CSS-Palm 4.0 score, PalmPred score
Color code for cysteine position:
Predicted (high confidence prediction with CSS-Palm or/and PalmPred) / Predicted but not validated (in terms of disulfide bond and cellular location) / Not predicted
Color code for CSS-Palm 4.0: High confidence,
Color code for PalmPred: High confidence (score > 0.4),
Medium confidence (0.1 > score > 0.4),
Low confidence (score < 0.1),